Page 106 - BIOCHEMISTRY II

5- Propionates

• Oxidation of fatty acids with an odd number of carbon
atoms and the oxidation of some amino acids generates as
the terminal oxidation product, propionyl-CoA. Propionyl-
CoA is converted to the TCA intermediate, succinyl-CoA.

• This conversion is carried out by the ATP-requiring
enzyme, propionyl-CoA carboxylase then methylmalonyl-
CoA epimerase and finally the vitamin B12 requiring
enzyme, methylmalonyl-CoA mutase.

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