Page 92 - BIOCHEMISTRY II

3-Lactic acidosis:

• It is the lowered blood pH and bicarbonate levels due
to increased blood lactate above normal. This
depletes bicarbonates decreasing pH of blood leading
to lactic acidosis which may be severe and cause
coma.

OH
CH3-C-COOH + NaHCO3 ----►CH3-C-COONa + H2CO3 ------► CO2 + H2O

• Causes:
– Increased formation of lactate as in severe
muscular exercise.

91