Page 70 - Clinical Biochemistry 08PB804
P. 70
Plavix: A story about effectiveness
• Anti-clotting drug
• Prescribed for coronary artery disease and those who have suffered a heart attack or stroke
or have a stent.
• A “pro-drug” Converted to active form in the liver by CYP2C19
Figure 36: Plavix
CYP2C19 mutant carriers had reduced presence of the active ingredient (pharmacokinetics)
and reduced ‘thinning’ (pharmacodynamics)
Figure 37: CYP2C19 mutant carriers
