Page 186 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Indications for combination antimicrobial therapy
a) Empirical treatment of life-threatening infections.
b) Treatment of polymicrobial infections.

c) Prevention of the emergence of bacterial resistance.

d) Decrease toxicity.

e) Synergism.

Types of interactions between antibiotics:

a) Antagonism

b) Additive

c) Synergism

Evaluation of antimicrobial combination
a) Checkerboard

b) Time-kill test (time-kill curve)

c) Disc diffusion test

d) The Epsilometer or E test

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