Page 104 - The Miracle in the Cell
P. 104

Blood capillary                  Blood capillary
                      1. The protein hormone diffuses  1. Steroid hormone diffuses from the
                      from the blood into the fluid   blood into the fluid between the cells.
                      between cells.
                                                                    Plasma
                                                 2. The hormone diffuses  membrane
                                                 through the cell mem-
                          Inactive receptor molecule  brane of the target cell.
                          found in the cell membrane              Cytoplasm
                          of the target cell
                                                 3. The hormone moves
                                                 into the nucleus and  Nucleus
                                                 binds with a receptor.
                 2. With the binding of the
                 hormone to the receptor, cer-   4. The hormone/receptor
                 tain enzymes are activated.     complex triggers the
                              3. The AMP molecule  reading of the desired  Receptor
                              activates new enzymes.  protein.        molecule
                                                 5. The relevant genes for
                   4. The activated enzymes cause  the desired protein are
                   changes in the cell activity (e.g., the  transferred into mRNA,
                   active transport of special molecules  which then moves  Reading of
                   across the cell membrane).    towards the cytoplasm.
                                                                  mRNA message



                                                       Hormones that bind
                                         Surface receptors to the surface recep-
                                                             tors
              Figure 5.6 a) In the first
              cell, calcium ions are
              present in low concen-
              trations. With the
              binding of certain      Calcium ions in low  Calcium ions in
              hormones (peptide or    concentrations   high concentrations
              protein hormones, or
              hormones such as
              epinephrine), the order     Transport proteins in the
              is given to increase the    blood
              calcium ion
              concentration.
              b) Certain hormones
                                                       Hormone
              (steroids, thyroxin)
              delivered via blood cir-                      Receptors
              culation and carried by
                                        Nucleus             Structure of the
              protein transporter mole-                     receptor/hormone
              cules, enter into the cell.
                                                            complex
              By binding to special
              receptors in the cell nucleus, they facilitate the reading of certain genes, allow-
              ing for production of the desired proteins.





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