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P. 135

The Blood Coagulation Mechanism

                                                         The figure below 44  illustrates the
                                                  coagulation mechanism of the blood. The
                                                clot is generated as a result of the chemical
                    Wound                           reactions of a series of substances in a
                    surface
                           Kallikrein  Prekallikrein  certain order. For dissolution of the clot, a
                                                 similarly complicated process takes place.
            Hageman     Hageman*


                    HMK
                      PTA         PTA*
                                                       Convertin
                                                       Konvertin  Preconvertin
                                                                Prekonvertin
                            Chrismas     Chrismas*
                                         Christmas*
                            Christmas
                                                     Doku
                    Antihemophilic  Antiherrofilli*  Tissue factor
                                 Antihemophilic*
                     Antihemofilli
                                                     faktörü
                                                                Antithrombin
                                          Stuart  Stuart        Antitrombin
                                   Proaccelerin
                                  Proakselerin  Accelerin
                                                      Thrombin
                                          Prothrombin  Trombin
                                                                (Fibrin)
                                                     Fibrinöjen
                  Thrombomodulin                    Fibrinogen  (Yumuflak P›ht›)
                                                               (soft clot)
                                     FSF      FSF*
                                Protein C*
                               Protein C*
                                                                   (Fibrin) Sert
                                                                    Fibrin
                                                                     P›ht›
                                                                   (hard clot)
                               Protein C                            Plasmin
                                                                           a2-antiplasmin
                                                              t-PA         a2 antiplazm
                                                                  Plasminogen




                      ●                  Proteins that are involved in promoting clot
                                                    formation
                                             Proteins that are involved in the
                      ●                    prevention, localization, or removal of
                                                   blood clots.
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