Page 24 - WNS 2022 PUBLICATION 5.5 X 8.5 - Text 4,25 X 7.5 incl. page number
P. 24

Basic Science Award




                                     Jacob Young

                                     University of California, San Francisco



                                     Reprogramming the glioblastoma immune
                                     microenvironment with convection enhanced
                                     gene therapy reveals intratumor IL6 drives
                                     glioblastoma immunosuppression and growth.

           Jacob (Jake) Young, MD is a UCSF neurosurgery resident with an interest
           in neurosurgical oncology and immunotherapy. His translational research
           focuses on novel gene therapy and immunotherapy for the treatment of
           high-grade gliomas and his clinical research investigates how brain mapping
           and state-of-the-art technology optimize functional outcomes and minimize
           complications after surgery for intrinsic brain tumors. Furthermore, he is
           involved in the development of early phase clinical trials to translate laboratory
           discoveries for patients with glioblastoma at UCSF. He works closely with
           mentors Mitchel Berger MD,    Manish Aghi MD PhD, Shawn Hervey-Jumper MD,
           Hideho Okada MD PhD, and David Raleigh MD PhD, on projects exploring these
           topics. In recognition of his research, Jake was selected to be a Physician-
           Scientist Fellow by the Chan-Zuckerberg Biohub, and he is the receipt of an
           American Society of Clinical Oncology Young Investigator Award. Additionally, his
           work has been supported by the National Cancer Institute, Glioblastoma Founda-
           tion, and American Association of Neurological Surgeons. Finally, Jake’s clinical
           care has been recognized with the Krevan’s Award for Excellence in Patient Care
           at the Zuckerberg San Francisco General Hospital, the Howard Naffziger Award
           for Outstanding Clinical Service and Care to neurosurgical patients at UCSF, and
           the 2020 Exceptional Physician Award from UCSF.
           Outside of neurosurgery, Jake enjoys running, playing basketball and tennis,
           and exploring new restaurants with his fiancé.


















                                         24
   19   20   21   22   23   24   25   26   27