Page 24 - WNS 2022 Program Book-Final version

Basic Science Award

Jacob Young

University of California, San Francisco

Reprogramming the glioblastoma immune
microenvironment with convection enhanced
gene therapy reveals intratumor IL6 drives
glioblastoma immunosuppression and growth.

Jacob (Jake) Young, MD is a UCSF neurosurgery resident with an interest
in neurosurgical oncology and immunotherapy. His translational research
focuses on novel gene therapy and immunotherapy for the treatment of
high-grade gliomas and his clinical research investigates how brain mapping
and state-of-the-art technology optimize functional outcomes and minimize
complications after surgery for intrinsic brain tumors. Furthermore, he is
involved in the development of early phase clinical trials to translate laboratory
discoveries for patients with glioblastoma at UCSF. He works closely with
mentors Mitchel Berger MD, Manish Aghi MD PhD, Shawn Hervey-Jumper MD,
Hideho Okada MD PhD, and David Raleigh MD PhD, on projects exploring these
topics. In recognition of his research, Jake was selected to be a Physician-
Scientist Fellow by the Chan-Zuckerberg Biohub, and he is the receipt of an
American Society of Clinical Oncology Young Investigator Award. Additionally, his
work has been supported by the National Cancer Institute, Glioblastoma Founda-
tion, and American Association of Neurological Surgeons. Finally, Jake’s clinical
care has been recognized with the Krevan’s Award for Excellence in Patient Care
at the Zuckerberg San Francisco General Hospital, the Howard Naffziger Award
for Outstanding Clinical Service and Care to neurosurgical patients at UCSF, and
the 2020 Exceptional Physician Award from UCSF.
Outside of neurosurgery, Jake enjoys running, playing basketball and tennis,
and exploring new restaurants with his fiancé.

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