Page 15 - NTM Insight Pamphlet 2024

Class
Medication Names (Brand Names)
Form
Notes
Common Side Effects
Aminoglycoside
Amikacin (Amikin®)
(ARIKAYCE®)+
FDA-approved to treat MAC lung disease
Tobramycin (TOBI®)#
Streptomycin
Injection, inhaled, IV
Inhaled
Inhaled, IV
Injection, IM
Patients on aminoglycosides should have a baseline hearing test before or at start of treatment. Hearing as well as BUN, creatinine, and electrolytes should be monitored at routine intervals while on therapy.
Hearing loss, tinnitus (ringing in the ears); nausea; muscle weakness; rash; poor balance; kidney problems; risk of increased respiratory adverse reactions (inhaled)
Fluoroquinolones (“Quinolone”)
Ciprofloxacin Pill (Cipro®)
Levofloxacin Pill (Levaquin®)
Moxifloxacin Pill (Avelox®)
Do not take a macrolide alone (monotherapy) or in combination with a quinolone as the only companion drug for the macrolide to treat MAC. This combination is associated with the emergence of macrolide resistance.
At-risk patients should check EKG for QTc interval prior to therapy and after treatment has started.
Upset stomach; rash; diarrhea; headache; loss of appetite; EKG abnormality in at-risk patients or
in combination with other medications; dizziness; tendon abnormalities; low blood sugar; adverse psychiatric reactions including depression
ntminfo.org
13