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Abstract

Objective

This study aimed to determine the effect of Photobiomodulation (PBM) in the treatment of recurrent
herpes labialis (RHL), one of the most common herpes simplex virus type 1 infections.

Material and Methods

In this single-blind randomized clinical trial, Twenty-four symptomatic patients with RHL were enrolled.
The patients were randomly allocated into the case (received 1% acyclovir cream with PBM 5 times a day

for 5 days and control groups who received acyclovir cream similar to the regimen of the treatment group
without PBM. The size of the lesions, and pain intensity (based on a visual analogue scale) were
considered as the outcome.

Results

Our ndings suggested that, pain intensity 48 hours and 72 hours after treatment in case group were
signi cantly p < 0.001). The lesion’s size was signi cantly reduced on the 7th and 10th days in the case
group (p < 0.05). Patients in the treatment group were signi cantly more satis ed with their treatment
process = group (p = 0.008).

Conclusion

The results of the present study showed that LLLP in addition with acyclovir cream could be more
e cient in treating pain intensity, lesion size, and recovery time in patients treated with recurrent herpes
labialis infection.

Clinical Relevance:

Low laser therapy can be used as an adjuvant therapeutic tool in combination with Acyclovir in patients
with Recurrent Herpes Labialis

Introduction

Recurrent herpes labialis (RHL), also known as fever blisters or cold sores is one of the most common

infections of the mouth and face caused by herpes simplex virus-1 (HSV1). RHL is a global health issue,
and occurs in approximately 20 to 40% of the young adult population [1–3]. The lips and around the
mouth are the most common sites for these lesions, however, lesions may also occur in other areas of the
face [4]. About 25% of seropositive cases develop recurrent infections 1 to 4 times per year and typically

these occur after stress, trauma, febrile illness, or immune suppression [5–7]. RHL begins with prodromal
symptoms such as burning, itching, and swelling, following, vesicular lesions gradually ulcerate and crust
over 72 to 96 hours [8]. The disease is self-limiting and resolves within 10 to 14 days [9].

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