Page 188 - 2014 Printable Abstract Book
P. 188
on Day 4 after irradiation (evidence of GI mitigation), SMA-011 was also tested in the partial body
irradiation model (abdominal region irradiated with a high irradiation dose). In summary, the low toxicity,
good systemic bioavailability, decrease in oxidative stress in mitochondria, proliferative effect and
significantly increased survival rate confirm that SMA-011 has a promising potential as a radiation
mitigating agent.
(PS2-88) Effects of a complex dietary supplement (CDS) on cognitive function, oxidative damage and
stress signalling in the brains of gamma irradiated mice. Kathleen A. Monster; Jennifer Lemon; David
Rollo; and Douglas Boreham, McMaster University, Hamilton, Canada
A complex dietary supplement (CDS) was originally designed to off-set 5 key mechanisms
associated with aging including oxidative damage, inflammation, impaired glucose metabolism,
mitochondrial dysfunction and membrane deterioration. Previous studies have shown profound
radioprotective properties in hematopoietic tissue and supplementation has had significant protective
effects in ameliorating cognitive function in an oxidative stress mouse model. A 5.0 Gy whole body dose
was used to induce oxidative stress and induce prolonged radiation-induced cognitive impairment. This
dose is high enough to induce hippocampal stem cell killing without significant acute radiation syndrome
in C57BL/6J and Tg (Thy1-EGFP) MJrs/J mice. Cognitive testing provided assessment of hippocampal
functioning including neurogenesis and executive functioning. Preliminary results indicate a protective
effect of supplementation on oxidative status as measured by total antioxidant capacity, HNE-protein
adducts and 8-OHdG (oxidative DNA base damage) in the brain and protection of stem cell function as
determined by preservation of olfaction, vision and coat colour. Our early results showed that after a 5.0
Gy dose, the mice on the diet had better smell, better vision, and coat colour was less grey. The results
indicate that the CDS has significant radioprotective properties. We will present data on the effects of the
supplement on oxidative damage and oxidative status in brain tissue as well as levels of stress response
molecules NRF2 and FOXO3.
186 | P a g e
irradiation model (abdominal region irradiated with a high irradiation dose). In summary, the low toxicity,
good systemic bioavailability, decrease in oxidative stress in mitochondria, proliferative effect and
significantly increased survival rate confirm that SMA-011 has a promising potential as a radiation
mitigating agent.
(PS2-88) Effects of a complex dietary supplement (CDS) on cognitive function, oxidative damage and
stress signalling in the brains of gamma irradiated mice. Kathleen A. Monster; Jennifer Lemon; David
Rollo; and Douglas Boreham, McMaster University, Hamilton, Canada
A complex dietary supplement (CDS) was originally designed to off-set 5 key mechanisms
associated with aging including oxidative damage, inflammation, impaired glucose metabolism,
mitochondrial dysfunction and membrane deterioration. Previous studies have shown profound
radioprotective properties in hematopoietic tissue and supplementation has had significant protective
effects in ameliorating cognitive function in an oxidative stress mouse model. A 5.0 Gy whole body dose
was used to induce oxidative stress and induce prolonged radiation-induced cognitive impairment. This
dose is high enough to induce hippocampal stem cell killing without significant acute radiation syndrome
in C57BL/6J and Tg (Thy1-EGFP) MJrs/J mice. Cognitive testing provided assessment of hippocampal
functioning including neurogenesis and executive functioning. Preliminary results indicate a protective
effect of supplementation on oxidative status as measured by total antioxidant capacity, HNE-protein
adducts and 8-OHdG (oxidative DNA base damage) in the brain and protection of stem cell function as
determined by preservation of olfaction, vision and coat colour. Our early results showed that after a 5.0
Gy dose, the mice on the diet had better smell, better vision, and coat colour was less grey. The results
indicate that the CDS has significant radioprotective properties. We will present data on the effects of the
supplement on oxidative damage and oxidative status in brain tissue as well as levels of stress response
molecules NRF2 and FOXO3.
186 | P a g e
