Page 413 - 2014 Printable Abstract Book
P. 413
assessment of CT-related radiation doses and corresponding risk in a South America population. The
project is supported by the Brazilian Federal Agency for the Support and Evaluation of Graduate
Education, (CAPES n°375/2013).
(PS7-62) Novel tool for estimating cumulated absorbed doses and associated risks of cataracts and
1;2
cancer for cardiology staff exposed occupationally to ionising radiation. James Grellier ; David
1;3
4
1
1
Morina ; Adela Carnic ; Eileen Pernot ; and Elisabeth Cardis , Centre for Research in Environmental
1
Epidemiology (CREAL), Barcelona, Spain ; Department of Epidemiology and Biostatistics, Imperial College,
2
London, United Kingdom ; GRAAL – Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma
3
de Barcelona, Barcelona, Spain ; and Institute of Radiation Physics (IRA), Department of Radiology, Centre
4
hospitalier universitaire vaudois (CHUV), Lausanne, Switzerland
Interventional cardiologists and electro physiologists are occupationally exposed to ionizing
radiation. The clinical benefits of using catheterization techniques instead of open surgery have resulted
in an increase in these clinicians’ workloads over the past two decades and, although concomitant
improvements in technology and radiation protection have reduced doses per procedure, there is concern
that cumulated doses may still result in increased risks of brain cancer and cataracts. Effective use of
radiation protection measures can reduce these risks by reducing doses to the brain and eye lens.
We designed a tool that employs robust estimators of parameters based on a multiple linear regression
of predictors of dose including radiation protection measures, catheterization access route, tube
configuration and operator experience (derived from data collected in the ORAMED project and from the
literature) and a user-defined occupational history to produce distributions of annual and total cumulated
absorbed doses to the targets of interest. Potential sources of uncertainty are taken into account by
means of Monte Carlo simulation. The user can reconstruction their occupational history either (a)
annually, by inputting data on number of specific procedures carried out, radiation protection measures
used, and X-ray tube configuration, or (b) using general data from existing databases. Changes in imaging
equipment available over the past four decades were taken into account by fitting a metaregression
model using results from a literature review. Computed doses are adjusted using these values.
Distributions of risk are calculated on the basis of resulting cumulated absorbed doses, using estimates of
dose-response and related uncertainties derived from the literature. In support of radiation protection,
the tool allows the user to compare doses and associated risks with those expected under scenario where
protective equipment is employed to the fullest extent or not employed at all.
Population attributable risks of both health outcomes can be calculated for populations of health
professionals for whom group-level occupational histories are reconstructed, thereby allowing estimation
of expected health benefits for populations associated with use of a variety of radiation protection
measures. Funding: This work was partially supported by grant 70203 from the Swiss Federal Office of
Public Health.
project is supported by the Brazilian Federal Agency for the Support and Evaluation of Graduate
Education, (CAPES n°375/2013).
(PS7-62) Novel tool for estimating cumulated absorbed doses and associated risks of cataracts and
1;2
cancer for cardiology staff exposed occupationally to ionising radiation. James Grellier ; David
1;3
4
1
1
Morina ; Adela Carnic ; Eileen Pernot ; and Elisabeth Cardis , Centre for Research in Environmental
1
Epidemiology (CREAL), Barcelona, Spain ; Department of Epidemiology and Biostatistics, Imperial College,
2
London, United Kingdom ; GRAAL – Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma
3
de Barcelona, Barcelona, Spain ; and Institute of Radiation Physics (IRA), Department of Radiology, Centre
4
hospitalier universitaire vaudois (CHUV), Lausanne, Switzerland
Interventional cardiologists and electro physiologists are occupationally exposed to ionizing
radiation. The clinical benefits of using catheterization techniques instead of open surgery have resulted
in an increase in these clinicians’ workloads over the past two decades and, although concomitant
improvements in technology and radiation protection have reduced doses per procedure, there is concern
that cumulated doses may still result in increased risks of brain cancer and cataracts. Effective use of
radiation protection measures can reduce these risks by reducing doses to the brain and eye lens.
We designed a tool that employs robust estimators of parameters based on a multiple linear regression
of predictors of dose including radiation protection measures, catheterization access route, tube
configuration and operator experience (derived from data collected in the ORAMED project and from the
literature) and a user-defined occupational history to produce distributions of annual and total cumulated
absorbed doses to the targets of interest. Potential sources of uncertainty are taken into account by
means of Monte Carlo simulation. The user can reconstruction their occupational history either (a)
annually, by inputting data on number of specific procedures carried out, radiation protection measures
used, and X-ray tube configuration, or (b) using general data from existing databases. Changes in imaging
equipment available over the past four decades were taken into account by fitting a metaregression
model using results from a literature review. Computed doses are adjusted using these values.
Distributions of risk are calculated on the basis of resulting cumulated absorbed doses, using estimates of
dose-response and related uncertainties derived from the literature. In support of radiation protection,
the tool allows the user to compare doses and associated risks with those expected under scenario where
protective equipment is employed to the fullest extent or not employed at all.
Population attributable risks of both health outcomes can be calculated for populations of health
professionals for whom group-level occupational histories are reconstructed, thereby allowing estimation
of expected health benefits for populations associated with use of a variety of radiation protection
measures. Funding: This work was partially supported by grant 70203 from the Swiss Federal Office of
Public Health.
