Page 97 - 2014 Printable Abstract Book
P. 97
increased treatment planning accuracy. These innovations, both in target delineation and in image
guidance, translate into better tumor control and fewer treatment related toxicities. A similar evolution
in treatment precision is occurring with pre-clinical tumor studies because of dedicated small animal
imaging devices (CT, PET and MR) coupled with innovative image-guided radiation delivery. This
presentation will discuss the use of small animal imaging and a small animal radiation research device for
the precise targeting of intra-cranial glioblastoma, orthotopic neuroblastoma and subcutaneous head and
neck tumors. The radiobiology of two distinct radiation schemes will be discussed through a comparison
of tumor outcome data generated after continuously-delivered standard radiotherapy using 2 Gy fractions
compared with low-dose pulsed radiotherapy (10 x 0.2 Gy). The biological rationale for using multiple low-
doses of 0.2 Gy to the same total dose is to avoid the activation of DNA double strand break detection
and repair processes via ATM-dependent damage and cell cycle checkpoint mechanisms. In addition, the
presentation will demonstrate that non-invasive tumor imaging using a range of PET isotopes (F18-FDG,
F18-MISO and F18-FLT) can be used to delineate radiation response in pre-clinical models throughout the
course of treatment to identify biological changes that are not evident from an assessment of tumor
volume.
S28 DOING MORE WITH LESS-COPING WITH SINGLE-DIGIT PAYLINES
The current payline for NIH funding is at an unprecedented low with little hope for improvement in the
immediate future. At the same time, institutional support for research is waning and many non-profit
foundations and other government funding agencies experience financial difficulties. Therefore, one has
to be creative, consider alternative research funding mechanisms, new research areas, and make do with
less than before. In this workshop, representatives for NCI’s Center for Scientific Review (CSR), Radiation
Research Program, Cancer Training Branch, and SBIR & STTR Programs will provide (very) brief
introductions to their specific areas of responsibility and then field questions from the moderators and
audience in the format of a panel discussion. The session is supposed to be highly interactive with a high
degree of audience participation. As a result of this workshop, the attendees will be able to improve their
skills at negotiating the current situation and will be helped in recognizing personal and programmatic
strengths.
(S2801) Panelist
Syed Quadri, NIH, Center for Scientific Review, Rockville, MD
(S2802) Panelist
Eric J. Bernhard, Oxford University, Headington Oxford, United Kingdom
(S2803) Panelist
Deepa Narayanan, National Institutes of Health, Bethesda, MD
(S2804) Panelist
Ming Lei, National Institutes of Health, Bethesda, MD
95 | P a g e
guidance, translate into better tumor control and fewer treatment related toxicities. A similar evolution
in treatment precision is occurring with pre-clinical tumor studies because of dedicated small animal
imaging devices (CT, PET and MR) coupled with innovative image-guided radiation delivery. This
presentation will discuss the use of small animal imaging and a small animal radiation research device for
the precise targeting of intra-cranial glioblastoma, orthotopic neuroblastoma and subcutaneous head and
neck tumors. The radiobiology of two distinct radiation schemes will be discussed through a comparison
of tumor outcome data generated after continuously-delivered standard radiotherapy using 2 Gy fractions
compared with low-dose pulsed radiotherapy (10 x 0.2 Gy). The biological rationale for using multiple low-
doses of 0.2 Gy to the same total dose is to avoid the activation of DNA double strand break detection
and repair processes via ATM-dependent damage and cell cycle checkpoint mechanisms. In addition, the
presentation will demonstrate that non-invasive tumor imaging using a range of PET isotopes (F18-FDG,
F18-MISO and F18-FLT) can be used to delineate radiation response in pre-clinical models throughout the
course of treatment to identify biological changes that are not evident from an assessment of tumor
volume.
S28 DOING MORE WITH LESS-COPING WITH SINGLE-DIGIT PAYLINES
The current payline for NIH funding is at an unprecedented low with little hope for improvement in the
immediate future. At the same time, institutional support for research is waning and many non-profit
foundations and other government funding agencies experience financial difficulties. Therefore, one has
to be creative, consider alternative research funding mechanisms, new research areas, and make do with
less than before. In this workshop, representatives for NCI’s Center for Scientific Review (CSR), Radiation
Research Program, Cancer Training Branch, and SBIR & STTR Programs will provide (very) brief
introductions to their specific areas of responsibility and then field questions from the moderators and
audience in the format of a panel discussion. The session is supposed to be highly interactive with a high
degree of audience participation. As a result of this workshop, the attendees will be able to improve their
skills at negotiating the current situation and will be helped in recognizing personal and programmatic
strengths.
(S2801) Panelist
Syed Quadri, NIH, Center for Scientific Review, Rockville, MD
(S2802) Panelist
Eric J. Bernhard, Oxford University, Headington Oxford, United Kingdom
(S2803) Panelist
Deepa Narayanan, National Institutes of Health, Bethesda, MD
(S2804) Panelist
Ming Lei, National Institutes of Health, Bethesda, MD
95 | P a g e
