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26 HEALTHCARE

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Trust your gut

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The role of the gut microbiome
The gut “microbiome” is the term for all the organisms in your gut. It’s a massive ecosystem made up of
trillions of bacteria, yeast, fungi, and viruses. The gut microbiome is involved in many gastrointestinal (GI)
functions including digestion, and the maintenance of normal gut physiology and health . 1

Gut dysbiosis has been associated with a number of GI conditions, including functional GI disorders
(FGIDs). Whilst it is not fully understood whether this is a cause or consequence, gut dysbiosis may trigger
a proinflammatory state which could contribute to the onset of FGIDs . This has led to the reclassification
1
of FGIDs, such as irritable bowel syndrome (IBS), as disorders of the microbiome-gut-brain axis 2,3

The role of probiotics in IBS

The gut microbiome of people with IBS may Therefore, the gut
differ from those of people without IBS 4,1 microbiota may be a
potential therapeutic
The gut microbiome may contribute to the target in the
pathophysiology of IBS 5 management of IBS

Respected Guidelines: The British Society of Gastroenterology (BSG) and European Society of Primary
Care Gastroenterology endorse probiotics as a potential IBS treatment, especially for abdominal pain and
lower gastrointestinal symptoms.
Duration Matters: The NICE and British Dietetic Association suggest trying probiotics for a minimum of 4
weeks , while the BSG recommends extending this period to 12 weeks for a comprehensive assessment .
6
7
Strain Specificity: Probiotic effects are unique to each strain, so choosing the right one matters.

Learn more www.precisionbiotics.science
1. Gomaa, EZ. Human Gut Microbiome in Health and Disease: a review. Antonie Van Leeuwenhoek. 2020; 113 (12):
2017-2040 2. Kennedy PJ, et al., A microbiome gut-brain axis disorder? World Journal of Gsatroenterology. 2014;
20 (39): 14104-14125 3. De Palma G, et al. The microbiota-gut-brain axis in functional gastrointestinal disorders. Gut
Microbes. 2014; 5 (3): 419-429 4. Whorwell PJ, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis
35624 in women with irritable bowel syndrome. American Journal of Gastroenterology. 2006;101(7):1581-1590.
5. Schmulson MJ, Drossman DA. What Is New in Rome IV. J Neurogastroenterol Motil. 017;23(2):151-163ISBNetwrok
Survey among consumers who tried Alflroex for 4 weeks 2019 6. NICE (2017) Irritable bowel syndrome in adults:
diagnosis and management (nice.org.uk) 7. Vasant DH, et al. 2021;70(7):1214-1240
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Up Off
Case Buying Trade POR To 29%
Product Size Size Price/Single RRP Offer % % Pip Code
ALFLOREX Trade
Alflorex Capsules 1 36 £10.41 £19.99 29% 38% 398-1206