Page 51 - P4403.14-V111 December OTC Magazine 2025 - Digital 1

GASTRO 51

AN INCREASING NUMBER OF PATIENTS

WITH HEARTBURN NEED YOUR ADVICE 6

Main drivers for increased prevalence include: 6,7

SEASONAL
LIFESTYLE AGE OBESITY
EVENTS
Certain food and In 2022, 19% of people In 2022 to 2023, Occasions such as
drink can trigger in the UK were aged 64% of adults in England Christmas, Easter, Eid,
heartburn or make it 65 or over. This is were estimated to be or summer barbecues
worse including coffee, projected to increase overweight or living may trigger increased
alcohol, chocolate and to 27% by 2072. 8 with obesity. 9 rates of heartburn.
fatty or spicy foods.
THE POWER OF NEXIUM CONTROL

FOR HEARTBURN RELIEF THE SCIENCE OF NEXIUM CONTROL

Acid reflux, a cause of heartburn, occurs GASTRIC PARIETAL CELL
Frequent heartburn (i.e. that occurs more than once a week) when the lower oesophageal sphincter AND PROTON PUMP
1
can significantly impact a patient’s quality of life. 2,3 relaxes, allowing excess stomach acid STOMACH ACID (HCl)
(HCl) to enter the oesophagus.
Proton Pump Inhibitors (PPIs) treat heartburn by targeting the source of excess stomach acid, Stomach acid is formed by the binding +
and are recommended by NICE guidelines as a first-line treatment for frequent heartburn. 4 of hydrogen (H+) and chloride (Cl-) ions HYDROGEN IONS (H )
produced by the gastric parietal cells CHLORIDE IONS (Cl )
–
GASTRIC PARIETAL CELL
AND PROTON PUMP
lining the stomach. 10 GASTRIC PARIETAL CELL
AND PROTON PUMP
Nexium Control works by irreversibly STOMACH ACID (HCl) NEXIUM CONTROL
GASTRIC PARIETAL CELL
binding to the enzyme proton pump that STOMACH ACID (HCl)
AND PROTON PUMP
GASTRIC PARIETAL CELL
AND PROTON PUMP
7s tablets 14s tablets 14s capsules 28s tablets allows the gastric parietal cells to secrete HYDROGEN IONS (H ) NEXIUM CONTROL GETS PROTON PUMP
+
STOMACH ACID (HCl)
HYDROGEN IONS (H )
H+ ions, preventing it from working. BEFORE TO WORK IN 1 HOUR* +
GASTRIC PARIETAL CELL
STOMACH ACID (HCl)
New to PPIs Value for recurrent AND PROTON PUMP
Patient need New to PPIs Easy to swallow This can start to work in 1 hour,* and CHLORIDE IONS (Cl )
–
looking for value sufferers HYDROGEN IONS (H ) CHLORIDE IONS (Cl )
–
+
reduces the production of stomach acid STOMACH ACID (HCl) HYDROGEN IONS (H )
+
for up to 24 hours to provide long-lasting NEXIUM CONTROL
–
heartburn relief. 11 CHLORIDE IONS (Cl ) + NEXIUM CONTROL –
CHLORIDE IONS (Cl )
HYDROGEN IONS (H )
PROTON PUMP
NEXIUM CONTROL GETS
BEFORE *full effect may take 2-3 days. NEXIUM CONTROL PROTON PUMP
TO WORK IN 1 HOUR*
–
BEFORE NEXIUM CONTROL GETS CHLORIDE IONS (Cl ) NEXIUM CONTROL
TO WORK IN 1 HOUR*
References: 1. Farup C, et al. Arch Intern Med. 2001 Jan 8;161(1):45-52. 2. Kulig M et al. Aliment Pharmacol Ther. 2003;18:767-76. 3. Ware JE Jr,
PROTON PUMP
Sherbourne CD. Med Care. 1992;30:473-83. 4. NICE guidelines CG184 Sept 2014. 5. Boardman HF, Heeley G. The role of the pharmacist in the selection
PROTON PUMP
NEXIUM CONTROL
NEXIUM CONTROL GETS
BEFORE and use of over-the-counter proton-pump inhibitors. Int J Clin Pharm. 2015 Oct;37(5):709-16. 6. Yamasaki T, et al. JNM Journal. 2018; 24(4). 7. HSE.
TO WORK IN 1 HOUR*
Active ingredient Esomeprazole Heartburn and acid reflux. 2021. Available at: https://www2.hse.ie/conditions/heartburn-and-acid-reflux/ . Accessed September 2024. 8. House of
NEXIUM CONTROL GETS
BEFORE
TO WORK IN 1 HOUR*
Commons Library. The UK’s changing population. July 2024. Available at: https://commonslibrary.parliament.uk/the-uks-changing-population.
Accessed October 2025. 9. Gov.uk. Obesity Profile: short statistical commentary May 2024. Available at: https://www.gov.uk/government/
PROTON PUMP
NEXIUM CONTROL GETS
Trial pack BEFORE statistics/update-to-the-obesity-profile-on-fingertips/obesity-profile-short-statistical-commentary-may-2024 . Accessed October 2025. 10. Hsu
TO WORK IN 1 HOUR*
M, Safadi AO, Lui F. Physiology, Stomach. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. 11. National Center
Start here for those using Complete 14-day Complete 14-day Value & convenience for Biotechnology Information (2024). PubChem Compound Summary for CID 9568614, Esomeprazole. Retrieved July 17, 2024 from https://pubchem.
Pack size role PPIs for the first time treatment pack treatment pack For recurrent sufferers ncbi.nlm.nih.gov/compound/Esomeprazole.
1 week supply Product information: Nexium Control 20 mg gastro-resistant tablets and Nexium Control 20mg gastro-resistant hard capsules.
Active ingredient: Esomeprazole Indications: The short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults.
Legal category: GSL: 14s capsules, 7s tablets, and 14s tablets P: 28s tablets. PL holder: Haleon UK Trading Limited, The Heights, Weybridge,
Surrey, KT13 0NY, U.K.
Information about these products, including adverse reactions, precautions, contraindications, and method of use can be found at:
https://www.medicines.org.uk/emc/product/819/smpc, https://www.medicines.org.uk/emc/product/14465/smpc
https://www.medicines.org.uk/emc/product/3660/smpc
Trade marks are owned by or licensed to the Haleon group of companies. PM-GB-NEX-25-00032.
29/10/2025 14:12
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