Page 21 - Practical-organic-3

Activity of 4-Hydroxy-phthalazinone Synthesis

1. Draw the chemical equation of 4-hydroxy-phthalazinone synthesis.

2. Mention one commercial drug containing phthalazinone nucleus & its uses.
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3. Calculate the needed amounts to do the reaction (in gram for solid & ml for
liquid) of 0.005 mol of phthalic anhydride and 0.005 mol of hydrazine hydrate,
then calculate the theoretical yield.

(M.Wt. of phthalic anhydride = 148.11 g)
(M.Wt. of hydrazine hydrate = 32.05 g & = 1.032 g/ml)
(M.Wt. of 4-hydroxy phthalazinone = 162.14 g)

Phthalic anhydride Hydrazine hydrate Theoretical yield
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