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1st Int. Transborder Conf. of the Timor Island: Timor %u2013 Science without borderDili, 7-8 May 202556Synthesis and Antibacterial Activity of C-Methoxyphenyl Alix[4]resorcin aryl octa cinnamate Compound Against Bacteria That Cause Banana DiseasesI G. M. N. Budiana1*, S. Widinugraheni2*, D. Tambaru2and F. Nitti31Deptartment of Chemistry, Faculty of Education and Teacher Training, Universitas Nusa Cendana, Indonesia.2 Department of Agrotechnology, Faculty of Agriculture, Universitas Nusa Cendana, Indonesia.3Department of Chemistry, Faculty of Sains and Technik, Universitas Nusa Cendana, Indonesia.*Corresponding authors: gusti_budiana@staf.undana.ac.id; widinugraheni@staf.undana.ac.idAbstractBanana blood disease (BDB) is a bacterial infection that primarily affects bananas, particularly those used as raw materials for processed banana products. The disease is characterized by rotting and browning of banana flesh, as well as leaf wilting. The causative agent of this disease is Ralstonia syzygii subsp. celebensis. This study focuses on evaluation of C-methoxy phenylcalix[4]resorcinaryl octacinnamate (CMPCROC). CMPCROC was synthesized through the esterification of C-methoxy phenylcalix[4]resorcinarene (CMPCR) using cinnamoyl chloride. The structure of the synthesized compound was characterized by IR, %u00b9H-NMR, and MS spectroscopy. Antibacterial activity was assessed using the Kirby-Bauer disc diffusion method. The synthesis yielded a yellow solid with a melting point of 215%u2013220 %u00b0C and a yield of 67.05%. Antibacterial testing revealed inhibition zone diameters for CMPCROC against Ralstonia syzygii subsp. celebensis at concentrations of 5%, 10%, and 20% as 0.93 cm, 0.63 cm, and 0.33 cm, respectively. For comparison, the positive control showed an inhibition zone diameter of 0.37 cm. These findings indicate that CMPCROC exhibits strong antibacterial activity against Ralstonia syzygii subsp. celebensis.Keywords: Synthesis, characterization, antibacterial activity, Ralstonia syzygii subsp. celebensis, banana blood disease