Page 21 - White Paper on Experimental Vaccines for Covid-19*

ADE is especially tricky because it is a delayed reaction. Initially all seems well. The
person seems to have a great immune response but then becomes deadly when the person is
exposed to the virus in the wild. It is well known that you must do animal testing first to try
to rule out ADE. Strong vaccine advocates Dr. Offit and Dr. Hotez, who would be expected
to be enthusiastic about these experimental vaccines, have not really endorsed these new
experimental vaccines, because previous coronavirus vaccines have a long history of
failure due to “antibody dependent enhancement.”

Antibody Dependent Enhancement (ADE), is when anti-COVID antibodies, created by a
vaccine, instead of protecting the person, cause a more severe or lethal disease when the
person is later exposed to SARS-CoV-2 in the wild. The vaccine amplifies the infection
rather than preventing damage. It may only be seen after months or years of use in
populations around the world. This paradoxical reaction has been seen in other vaccines
and animal trials. One well-documented example is with the Dengue fever vaccine, which
35 36
resulted in avoidable deaths. ,

Dengue fever has 100-400 million infections, 500,000 hospitalizations, and a 2.5% fatality

rate annually worldwide. It is a leading cause of death in children in Asian and Latin
American countries. Despite over 50 years of active research, a Dengue vaccine still has
37
not gained widespread approval in large part due to ADE. Sanofi Pharmaceutical spent 20

35 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642463/
36 https://www.nature.com/scitable/topicpage/host-response-to-the-dengue-virus-22402106/
37 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642463/
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