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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)


                Recurrence of BD means the return of symptoms e.g. mania, hypomania or depression after
            a period of wellness (symptom-free period). In a systematic review, factors associated with
            Recurrence of BD means the return of symptoms e.g. mania, hypomania or depression after
            Recurrence of BD means the return of symptoms e.g. mania, hypomania or depression after
                            8, level II-2

            recurrence of BD were:
            a period of wellness (symptom-free period). In a systematic review, factors associated with
            a period of wellness (symptom-free period). In a systematic review, factors associated with
                early age of onset
                            8, level II-2
            recurrence of BD were: 8, level II-2
            recurrence of BD were:
                low socio-economic status
                early age of onset
                early age of onset
                family history of BD
                low socio-economic status
                low socio-economic status
                history of child abuse
                family history of BD
                family history of BD
                low maternal warmth
                history of child abuse
                history of child abuse
                low maternal warmth
                co-morbid  mental  health  disorders  (anxiety  disorder,  ADHD  and  substance  use
                low maternal warmth
                co-morbid
                disorders)  mental  health  disorders  (anxiety  disorder,  ADHD  and  substance  use
                co-morbid  mental  health  disorders  (anxiety  disorder,  ADHD  and  substance  use
                disorders)
                inter-episode subsyndromal mood symptoms
                disorders)
                 inter-episode subsyndromal mood symptoms
                   inter-episode subsyndromal mood symptoms
                3.   SCREENING AND DIAGNOSIS
                3.   SCREENING AND DIAGNOSIS
            3.   SCREENING AND DIAGNOSIS

            The diagnosis of BD relies on signs and symptoms elicited during clinical interviews with the
              The diagnosis of BD relies on signs and symptoms elicited during clinical interviews with the
            patient and often with corroborative history from informants. Diagnostic and Statistical Manual
            The diagnosis of BD relies on signs and symptoms elicited during clinical interviews with the
            patient and often with corroborative history from informants. Diagnostic and Statistical Manual
            of Mental Disorders Fifth Edition, text revision (DSM-5-TR) and International Classification of
            patient and often with corroborative history from informants. Diagnostic and Statistical Manual
            of Mental Disorders Fifth Edition, text revision (DSM-5-TR) and International Classification of
            Diseases Eleventh Revision (ICD-11) classification system for psychiatric disorders assist in
            of Mental Disorders Fifth Edition, text revision (DSM-5-TR) and International Classification of
            Diseases Eleventh Revision (ICD-11) classification system for psychiatric disorders assist in
            framing operational definitions i.e. making diagnoses for clinical work and research. Revisions
            Diseases Eleventh Revision (ICD-11) classification system for psychiatric disorders assist in
            framing operational definitions i.e. making diagnoses for clinical work and research. Revisions
            of these classifications ensure they are at pace with the recent advancements in the field. The
            framing operational definitions i.e. making diagnoses for clinical work and research. Revisions
            of these classifications ensure they are at pace with the recent advancements in the field. The
            main changes in the new classification systems are:
            of these classifications ensure they are at pace with the recent advancements in the field. The
            main changes in the new classification systems are:
                both ICD-11 and DSM-5-TR use the term bipolar disorder instead of bipolar affective
            main changes in the new classification systems are:
                both ICD-11 and DSM-5-TR use the term bipolar disorder instead of bipolar affective
                disorder as in ICD-10
                both ICD-11 and DSM-5-TR use the term bipolar disorder instead of bipolar affective
                disorder as in ICD-10
                ICD-11 uses subdivision of bipolar disorder type I and II, in line with DSM-5-TR
                disorder as in ICD-10
                ICD-11 uses subdivision of bipolar disorder type I and II, in line with DSM-5-TR
                definitions  of  manic  and  hypomanic  syndromes  and  episodes  are  almost  identical
                ICD-11 uses subdivision of bipolar disorder type I and II, in line with DSM-5-TR
                definitions  of  manic  and  hypomanic  syndromes  and  episodes  are  almost  identical
                between ICD-11 and DSM-5-TR
                between ICD-11 and DSM-5-TR
                definitions  of  manic  and  hypomanic  syndromes  and  episodes  are  almost  identical
            Refer to Appendix 3 for Diagnostic Criteria of Bipolar Disorder Based on the Diagnostic
                between ICD-11 and DSM-5-TR
            Refer to Appendix 3 for Diagnostic Criteria of Bipolar Disorder Based on the Diagnostic
            and Statistical Manual of Mental Disorders Fifth Edition, Text Revision (DSM-5-TR) and
            and Statistical Manual of Mental Disorders Fifth Edition, Text Revision (DSM-5-TR) and
            Refer to Appendix 3 for Diagnostic Criteria of Bipolar Disorder Based on the Diagnostic
            International Classification of Diseases Eleventh Revision (ICD-11).
            and Statistical Manual of Mental Disorders Fifth Edition, Text Revision (DSM-5-TR) and
            International Classification of Diseases Eleventh Revision (ICD-11).

              International Classification of Diseases Eleventh Revision (ICD-11).
              Recommendation 1
             Recommendation 1
               Bipolar Disorder should be diagnosed based on the Diagnostic and Statistical Manual of
               Bipolar Disorder should be diagnosed based on the Diagnostic and Statistical Manual of
             Recommendation 1
               Mental Disorders Fifth Edition, Text Revision or International Classification of Diseases
               Mental Disorders Fifth Edition, Text Revision or International Classification of Diseases
               Bipolar Disorder should be diagnosed based on the Diagnostic and Statistical Manual of
               Eleventh Revision.
               Mental Disorders Fifth Edition, Text Revision or International Classification of Diseases
               Eleventh Revision.
               Eleventh Revision.

            3.1.  Screening Tools
              3.1.  Screening Tools
                3.1.  Screening Tools
            BD commonly presents as unipolar depression on the first presentation. There is a prevalence
              BD commonly presents as unipolar depression on the first presentation. There is a prevalence
            of 17% of undiagnosed BD in primary care, amounting to over 3 in every 20 patients.
                                                                     9, level II-2
            of 17% of undiagnosed BD in primary care, amounting to over 3 in every 20 patients. 9, level II-2
            BD commonly presents as unipolar depression on the first presentation. There is a prevalence
            This may lead to a misdiagnosis or delayed diagnosis of BD up to 10 years, which in turn may
            This may lead to a misdiagnosis or delayed diagnosis of BD up to 10 years, which in turn may
            of 17% of undiagnosed BD in primary care, amounting to over 3 in every 20 patients.
                                                                     9, level II-2
            result  in  an  increased  risk  of  treatment-emergent  mania/hypomania  and  suicide.
                                                                       10-12
                                                                      10-12
            result  in  an  increased  risk  of  treatment-emergent  mania/hypomania  and  suicide.
            This may lead to a misdiagnosis or delayed diagnosis of BD up to 10 years, which in turn may
            Screening tools for BD may assist healthcare practitioners in identifying those with underlying
            Screening tools for BD may assist healthcare practitioners in identifying those with underlying
            result  in  an  increased  risk  of  treatment-emergent  mania/hypomania  and  suicide.
                                                                       10-12
            BD. Furthermore, identifying those who are at risk of BD allows for preventive strategies and
            BD. Furthermore, identifying those who are at risk of BD allows for preventive strategies and
            Screening tools for BD may assist healthcare practitioners in identifying those with underlying
            early interventions.
            early interventions.
            BD. Furthermore, identifying those who are at risk of BD allows for preventive strategies and


            early interventions.
            The following tools are available for the screening of BD:
            The following tools are available for the screening of BD:

                Mood disorder questionnaire (MDQ)
                                        13
                Mood disorder questionnaire (MDQ)
                                       13
            The following tools are available for the screening of BD:
                Hypomania checklist (HCL-32)
                                    14
                Hypomania checklist (HCL-32)    13
                                    14
                Mood disorder questionnaire (MDQ)
                Bipolar spectrum diagnostic scale (BSDS)
                Bipolar spectrum diagnostic scale (BSDS) 15 15
                                    14
                Hypomania checklist (HCL-32)
                Rapid mood screener (RMS) 16 16  15
                Rapid mood screener (RMS)
                Bipolar spectrum diagnostic scale (BSDS)
            Refer Appendix 4 for List of Screening Tools in Bipolar Disorder.
            Refer Appendix 4 for List of Screening Tools in Bipolar Disorder.
                                   16
                   Rapid mood screener (RMS)
            Refer Appendix 4 for List of Screening Tools in Bipolar Disorder.

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