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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)




            this should be maintained in the treatment of BD despite the mixed results and quality of the
            this should be maintained in the treatment of BD despite the mixed results and quality of the
            this should be maintained in the treatment of BD despite the mixed results and quality of the
            latest evidence.
            this should be maintained in the treatment of BD despite the mixed results and quality of the
            latest evidence.
            latest evidence.

            latest evidence.


              Recommendation 7
             Recommendation 7
             Recommendation 7
               Psychosocial  interventions  and  psychotherapies  should  be  offered  as  an  adjunctive
             Recommendation 7
               Psychosocial  interventions  and  psychotherapies  should  be  offered  as  an  adjunctive
               Psychosocial  interventions  and  psychotherapies  should  be  offered  as  an  adjunctive
               treatment for bipolar disorder.
               Psychosocial  interventions  and  psychotherapies  should  be  offered  as  an  adjunctive
               treatment for bipolar disorder.
               treatment for bipolar disorder.
                         treatment for bipolar disorder.

            5.
              5.
                COMPLEMENTARY AND ALTERNATIVE THERAPIES
                COMPLEMENTARY AND ALTERNATIVE THERAPIES
            5.

                COMPLEMENTARY AND ALTERNATIVE THERAPIES
            5.   COMPLEMENTARY AND ALTERNATIVE THERAPIES


            Persons  with  BD  often  self-medicate  themselves  with  complementary  and  alternative

            Persons  with  BD  often  self-medicate  themselves  with  complementary  and  alternative
            Persons  with  BD  often  self-medicate  themselves  with  complementary  and  alternative
            medicine (CAM) despite limited evidence supporting their use.
                                                     85
                                                     85
            Persons  with  BD  often  self-medicate  themselves  with  complementary  and  alternative
            medicine (CAM) despite limited evidence supporting their use.
            medicine (CAM) despite limited evidence supporting their use.
                                                     85

            medicine (CAM) despite limited evidence supporting their use.
                                                     85


            Complementary therapies mentioned in RANZCP include regular exercise being associated
              Complementary therapies mentioned in RANZCP include regular exercise being associated
            Complementary therapies mentioned in RANZCP include regular exercise being associated
                                                              39
            with improved QoL, although its benefits in BD remain less clearly defined.
            Complementary therapies mentioned in RANZCP include regular exercise being associated
            with improved QoL, although its benefits in BD remain less clearly defined.  Meanwhile, in a
            with improved QoL, although its benefits in BD remain less clearly defined.  Meanwhile, in a
                                                              39
            systematic review of nutraceuticals use in BD, there was promising, albeit conflicting evidence
                                                              39
            with improved QoL, although its benefits in BD remain less clearly defined.  Meanwhile, in a
            systematic review of nutraceuticals use in BD, there was promising, albeit conflicting evidence
                                                     86ng, albeit conflicting evidence
            systematic review of nutraceuticals use in BD, there was promisi
                                                     86
            for omega-3 fatty acids, N-acetylcysteine and coenzyme Q10.
            systematic review of nutraceuticals use in BD, there was promising, albeit conflicting evidence
            for omega-3 fatty acids, N-acetylcysteine and coenzyme Q10.
                                                     86
              for omega-3 fatty acids, N-acetylcysteine and coenzyme Q10.
            for omega-3 fatty acids, N-acetylcysteine and coenzyme Q10.    39  Meanwhile, in a
                                                     86


              Meanwhile, in  Malaysia, among the common alternative therapies used are cannabis and
            Meanwhile, in  Malaysia, among the common alternative therapies used are cannabis and
            Meanwhile, in  Malaysia,
                       87, level  III among the common alternative therapies used are cannabis and
            kratom (ketum).
                       87, level  III  Interactions between cannabis use (CU) and BD  are complex and
            Meanwhile, in  Malaysia, among the common alternative therapies used are cannabis and
                             Interactions between cannabis use (CU) and BD  are complex and
                             Interactions between cannabis use (CU) and BD  are complex and
            kratom (ketum).
            kratom (ketum).87, level  III
                       87, level  III one may contribute to the other. The prevalence of CU is increasing
            bidirectional whereby
            kratom (ketum).
                             Interactions between cannabis use (CU) and BD  are complex and
            bidirectional whereby one may contribute to the other. The prevalence of CU is increasing
            bidirectional whereby one may contribute to the other. The prevalence of CU is increasing
            globally and yet there’s limited research done on the treatment options for co-morbid BD and
            bidirectional whereby one may contribute to the other. The prevalence of CU is increasing
            globally and yet there’s limited research done on the treatment options for co-morbid BD and
            globally and yet there’s limited research done on the treatment options for co-morbid BD and
               40
            CU.
               40
            globally and yet there’s limited research done on the treatment options for co-morbid BD and
            CU.
            CU.
               40

            CU.
               40


            In  a  systematic  review,  a  case  series  on  patients  diagnosed  with  BD  and  treated  with
              In  a  systematic  review,  a  case  series  on  patients  diagnosed  with  BD  and  treated  with
            cannabidiol  (CBD)  monotherapy  showed  no  therapeutic  benefits  in  improving  manic
            In  a  systematic  review,  a  case  series  on  patients  diagnosed  with  BD  and  treated  with
            cannabidiol  (CBD)  monotherapy  showed  no  therapeutic  benefits  in  improving  manic
                                                        88, level III in  improving  manic
            cannabidiol  (CBD)  monotherapy  showed  no  therapeutic  benefits
                                                        88, level III
            symptoms compared with the combination of olanzapine and CBD.
            cannabidiol  (CBD)  monotherapy  showed  no  therapeutic  benefits  in  improving  manic

            symptoms compared with the combination of olanzapine and CBD.
            symptoms compared with the combination of olanzapine and CBD.88, level III


            symptoms compared with the combination of olanzapine and CBD.

                                                        88, level III


            Moreover, the CANMAT Task Force Report 2022 showed that CU in BD was associated with
              Moreover, the CANMAT Task Force Report 2022 showed that CU in BD was associated with
            Moreover, the CANMAT Task Force Report 2022 showed that CU in BD was associated with
            a worsened illness course, decreased functionality and increased mortality through suicide.
                                                                         89
                                                                         89
            Moreover, the CANMAT Task Force Report 2022 showed that CU in BD was associated with
            a worsened illness course, decreased functionality and increased mortality through suicide. 89
            a worsened illness course, decreased functionality and increased mortality through suicide.

                                                                         89
            a worsened illness course, decreased functionality and increased mortality through suicide.


              In  a  systematic  review,  a  case  series  on  patients  diagnosed  with  BD  and  treated  with
               There is insufficient evidence for the use of cannabis and kratom in the treatment of BD.
               There is insufficient evidence for the use of cannabis and kratom in the treatment of BD.
               There is insufficient evidence for the use of cannabis and kratom in the treatment of BD.
                 There is insufficient evidence for the use of cannabis and kratom in the treatment of BD.

                    6.   FOLLOW-UP/MONITORING AND REFERRAL
              6.
                FOLLOW-UP/MONITORING AND REFERRAL
            6.
                FOLLOW-UP/MONITORING AND REFERRAL

            6.
                FOLLOW-UP/MONITORING AND REFERRAL


            When managing BD, exploring several key aspects to provide effective care during follow-up
              When managing BD, exploring several key aspects to provide effective care during follow-up
            When managing BD, exploring several key aspects to provide effective care during follow-up
            is crucial. Monitoring symptoms over time is essential to assess the response to treatment and
            When managing BD, exploring several key aspects to provide effective care during follow-up
            is crucial. Monitoring symptoms over time is essential to assess the response to treatment and
            is crucial. Monitoring symptoms over time is essential to assess the response to treatment and
            the current state, whether in stable, remission or relapse. Besides that, it is important to review
            is crucial. Monitoring symptoms over time is essential to assess the response to treatment and
            the current state, whether in stable, remission or relapse. Besides that, it is important to review
            the current state, whether in stable, remission or relapse. Besides that, it is important to review
            the compliance with medication and presence of AEs.
            the current state, whether in stable, remission or relapse. Besides that, it is important to review
            the compliance with medication and presence of AEs.
            the compliance with medication and presence of AEs.

            the compliance with medication and presence of AEs.


            6.1.  Parameters to be Monitored during Maintenance Phase
              6.1.  Parameters to be Monitored during Maintenance Phase
            6.1.  Parameters to be Monitored during Maintenance Phase

            6.1.  Parameters to be Monitored during Maintenance Phase


            Parameters recommended to be monitored during the maintenance phase of BD at regular
              Parameters recommended to be monitored during the maintenance phase of BD at regular
            Parameters recommended to be monitored during the maintenance phase of BD at regular
                     6
                     6
            intervals are:
            Parameters recommended to be monitored during the maintenance phase of BD at regular
            intervals are:   6
            intervals are:
                weight
            intervals are:
                     6
                weight
                weight
                height
                weight
                height
                height
                waist circumference
                height
                waist circumference
                waist circumference
                blood pressure
                waist circumference
                blood pressure
                blood pressure
                electrocardiogram (ECG)
                blood pressure
                electrocardiogram (ECG)
                electrocardiogram (ECG)
                full blood count
                electrocardiogram (ECG)
                full blood count
                full blood count
                fasting blood sugar
                full blood count
                fasting blood sugar
                fasting blood sugar
                fasting blood sugar
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