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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

- Strong alkali (NaOH) results in opening of lactone ring to yield the carboxylic acid
salt.

4-Drying and storage:

▪ cardiac glycosides containing drugs must contain not more than specific moisture
content, It should be stored in sealed containers over dehydrating agents.

▪ It is sometimes recommended to heat-stabilize these cardiac drugs by destroying the
enzyme at high temperature. However, at much elevated temperature the tertiary
hydroxyl group at C-14 may split off as water, with the formation of an inactive
anhydro-form of the cardiac glycoside.

Chemical tests for Identification

- 1 Reactions due to the steroidal nucleus:

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