Page 193 - DUOKOPT BIBLIOBOOK

EFFICACY/TOLERABILITY

TOLERABILITY AND EFFECTIVENESS OF PF DORZOLAMIDE-

TIMOLOL (PF COSOPT) IN PATIENTS WITH OPEN-ANGLE

GLAUCOMA OR OCULAR HYPERTENSION

Hutnik C, et al. Clin Ophthalmol. 2010 Jul 21;4:581-90.

ABSTRACT

PURPOSE: To assess the effect of preservative-free dorzolamide–timolol on nonvisual symptoms
and IOP in newly diagnosed and untreated patients with OAG or ocular hypertension.

METHODS: Prospective, 8-week, open-label, Canadian multicenter study.

All 178 patients were treated with preservative-free dorzolamide-timolol formulation.
Primary tolerability outcome : change in the nonvisual symptom score of the Glaucoma Symptom
Scale (GSS-SYMP-6) from baseline to 8 weeks.

The GSS –SYMP-6 (extracted from the 10-item GSS) evaluates 6 nonvisual symptoms: 1.burning,
smarting, stinging, 2.watering, 3.sensation of dry eye, 4.itching, 5.pain and 6.feeling of eyestrain, foreign
body feeling).
Each of these 6 items is graded from 0 to 4 (0 = very bothersome, 4 = absent). The score is expressed
on a scale ranging from 0 to 100, lower scores showing higher symptom severity.

STUDY CRITERIA: Satisfaction, local tolerability.

RESULTS: The mean (SD) GSS-SYMP-6 score increased from 73.6 (±21.8) at baseline to :
74.5 (±19.3) at week 4 (NS) and 76.1 (±20.7) at week 8 (P = 0.097).

Figure 11: Patients’ and ophthalmologists’ satisfaction

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