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EFFICACY/TOLERABILITY
IMPROVEMENT IN GLAUCOMA PATIENTS QUALITY OF LIFE
BY THERAPY SWITCH TO PRESERVATIVE FREE TIMOLOL/
DORZOLAMIDE FIXED COMBINATION
(THE COSOPTUD STUDY GROUP)
Pinto LA, et al. Ophthalmologica – Published on line December 2013
ABSTRACT
PURPOSE: To assess a change in visual-related quality of life in glaucoma patients after switching from
preservative-containing medical therapy to PF unit dose (UD) DTFC.
METHODS: Prospective, non-interventional, multicenter 8-week study with 80 medically treated
glaucoma patients completed the study. Patients were switched from preservative-containing
IOP-lowering treatment to preservative-free DTFC.
Primary otucomes was a change in visual symptoms at week 8 and 4, assessed by GSS-SYMP and
change in GSS-FUNC at week 8 and 4.
STUDY CRITERIA: The GSS (Glaucoma Symptom Scale) which evaluates the ocular complaints from
the symptomatic point of view and from the functional point of view with 10 items as for instance :
watering, blurred vision and halos around lights.
The score is expressed on a scale ranging from 0 to 100, lower scores showing higher symptom se-
verity.
RESULTS: GSS-SYMP score improved at week 4 and 8, improved by 10 points at week 8, with a statis-
tical significance but no clinical relevance.
The improvement was also significant for GSS total score at both endpoints.
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