Page 38 - Exosomes - wound healing power

Pak et al Dovepress

Authors’ conclusion ASC+PRP+HA: effective in repairing meniscal tears Allogeneic culture‑ expanded bone marrow‑derived MSCs (non‑control group) are effective in regenerating meniscus and improving symptoms ASC+PRP+HA: effective in repairing meniscal tears Culture‑expanded, autologous bone marrow‑derived stem cells + collagen‑scaffold: effective in repairing meniscal tears

Results VAS/function improvements and MRI evidence of meniscus cartilage regeneration VAS and Lysholm improvements and MRI evidence of meniscus cartilage regeneration in non‑control groups VAS/function improvements and MRI evidence of cartilage regeneration Three of five patients showed function improvements and MRI evidence of meniscal repair

Outcome measures VAS; functions (FRI, ROM); MRI VAS; functions (Lysholm); MRI VAS; functions (FRI, ROM); MRI Functions (IKDC score, ROM, Tegner– Lysholm score); MRI

Follow-up (months) 24 24 3 24

For personal use only. Open Access Journal of Sports Medicine downloaded from https://www.dovepress.com/ by 68.175.65.102 on 25-Mar-2017 Concurrent treatment None Partial arthroscopic meniscectomy None None

Previous therapy Various conservative treatments without success None 3 months prior Various conservative treatments without any success None Abbreviations: ASC, adipose tissue‑derived stem cells; F, female; FRI, functional rate index; HA, hyaluronic acid; IKDC, International Knee Document Committee; Lysholm, Lysholm scores; M, male; MRI, magnetic resonance imaging; MSC,

Table 1 Current and clinical use of MSCs for human knee meniscus tears
Subject characteristic (age [year]; gender) Mean 47.8 (range: 18–78); 20 M Mean 51.6 (range: 29–77); 12 F Mean 46.0 (range: 18–60); 38 M and 17 F 32; 1 F with chronic knee pain due to meniscus tear Median 37 (range: 30–38); 4 M ND; 1 M mesenchymal stem cell; ND, not described; PRP, platelet‑rich plasma; ROM, range of motion; SVF, stromal vascular fraction; VAS, visual analogue scale; yr, years.

Number of subjects 32 55 1 5

Study type Cohort study Randomized, double‑blind, placebo‑ controlled study: MSCs vs HA vehicle control Case report Prospective open‑label study

Intervention treatment Adipose SVF (ASC)+PRP+HA via percutaneous injections Culture expanded, allogeneic bone marrow‑derived stem cells via intra‑articular injections Adipose SVF (ASC) +PRP+HA via percutaneous injections Culture‑expanded, autologous bone marrow‑derived stem cells + collagen‑scaffold via arthroscopic implantation Note: Tegner, Tegner activity scale.

Study (year) Pak et al 20 Vangsness et al 16 Pak et al 19 Whitehouse et al 34

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