Page 8 - Sexual Health Treatments
P. 8
Adipose-Derived Stem Cells and Erectile Dysfunction 327
following bilateral cavernous nerve crush injury in 39 Rider DA, Dombrowski C, Sawyer AA, Ng GH,
the rat. J Sex Med 2007;4:341–6, discussion 346– Leong D, Hutmacher DW, Nurcombe V, Cool SM.
7. Autocrine fibroblast growth factor 2 increases the
30 Fandel TM, Bella AJ, Lin G, Tantiwongse K, Lin multipotentiality of human adipose-derived mesen-
CS, Pohl J, Lue TF. Intracavernous growth differ- chymal stem cells. Stem Cells 2008;26:1598–608.
entiation factor-5 therapy enhances the recovery of 40 Suga H, Eto H, Shigeura T, Inoue K, Aoi N, Kato
erectile function in a rat model of cavernous nerve H, Nishimura S, Manabe I, Gonda K, Yoshimura K.
injury. J Sex Med 2008;5:1866–75. Ifats series: FGF-2-induced HGF secretion by
31 Bivalacqua TJST. The use of gene transfer technol- adipose-derived stromal cells inhibits post-injury
ogy to study the pathophysiology of erectile dys- fibrogenesis through a JNK-dependent mechanism.
function. J Sex Med 2008;5:268–75. Stem Cells 2008 [Epub ahead of print]. DOI:
32 Bivalacqua TJ, Deng W, Champion HC, Hellstrom 10.1634/stemcells.2008-0261.
WJ, Kadowitz PJ. Gene therapy techniques for the 41 Zaragosi LE, Ailhaud G, Dani C. Autocrine fibro-
delivery of endothelial nitric oxide synthase to the blast growth factor 2 signaling is critical for self-
corpora cavernosa for erectile dysfunction. Methods renewal of human multipotent adipose-derived stem
Mol Biol 2004;279:173–85. cells. Stem Cells 2006;24:2412–9.
33 Bivalacqua TJ, Deng W, Kendirci M, Usta MF, 42 Canguven O, Burnett A. Cavernous nerve injury
Robinson C, Taylor BK, Murthy SN, Champion using rodent animal models. J Sex Med 2008;5:
HC, Hellstrom WJ, Kadowitz PJ. Mesenchymal 1776–85.
stem cells alone or ex vivo gene modified with 43 Deng W, Bivalacqua TJ, Chattergoon NN, Hyman
endothelial nitric oxide synthase reverse age- AL, Jeter JR Jr, Kadowitz PJ. Adenoviral gene trans-
associated erectile dysfunction. Am J Physiol Heart fer of eNOS: High-level expression in ex vivo
Circ Physiol 2007;292:H1278–90. expanded marrow stromal cells. Am J Physiol Cell
34 Bochinski D, Lin GT, Nunes L, Carrion R, Physiol 2003;285:C1322–9.
Rahman N, Lin CS, Lue TF. The effect of 44 Song YS, Lee HJ, Park IH, Kim WK, Ku JH, Kim
neural embryonic stem cell therapy in a rat model SU. Potential differentiation of human mesenchy-
of cavernosal nerve injury. BJU Int 2004;94:904– mal stem cell transplanted in rat corpus cavernosum
9. toward endothelial or smooth muscle cells. Int J
35 Allera-Moreau C, Delluc-Clavieres A, Castano C, Impot Res 2007;19:378–85.
Van den Berghe L, Golzio M, Moreau M, Teissie J, 45 Nolazco G, Kovanecz I, Vernet D, Gelfand RA,
Arnal JF, Prats AC. Long term expression of bicis- Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-
tronic vector driven by the fgf-1 ires in mouse Cadavid NF. Effect of muscle-derived stem cells on
muscle. BMC Biotechnol 2007;7:74. the restoration of corpora cavernosa smooth muscle
36 Gonda K, Shigeura T, Sato T, Matsumoto D, Suga and erectile function in the aged rat. BJU Int
H, Inoue K, Aoi N, Kato H, Sato K, Murase S, 2008;101:1156–64.
Koshima I, Yoshimura K. Preserved proliferative 46 Song YS, Lee HJ, Park IH, Lim IS, Ku JH, Kim SU.
capacity and multipotency of human adipose- Human neural crest stem cells transplanted in rat
derived stem cells after long-term cryopreservation. penile corpus cavernosum to repair erectile dysfunc-
Plast Reconstr Surg 2008;121:401–10. tion. BJU Int 2008;102:220–4, discussion 224.
37 Gonzalez-Herrera IG, Prado-Lourenco L, Pileur F, 47 Garcia-Olmo D, Garcia-Arranz M, Herreros D.
Conte C, Morin A, Cabon F, Prats H, Vagner S, Expanded adipose-derived stem cells for the treat-
Bayard F, Audigier S, Prats AC. Testosterone regu- ment of complex perianal fistula including Crohn’s
lates FGF-2 expression during testis maturation by disease. Expert Opin Biol Ther 2008;8:1417–23.
an IRES-dependent translational mechanism. Faseb 48 Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk
J 2006;20:476–8. PA, Rodriguez LV. Processed lipoaspirate cells for
38 Kakudo N, Shimotsuma A, Kusumoto K. Fibroblast tissue engineering of the lower urinary tract: Impli-
growth factor-2 stimulates adipogenic differentia- cations for the treatment of stress urinary inconti-
tion of human adipose-derived stem cells. Biochem nence and bladder reconstruction. J Urol 2005;
Biophys Res Commun 2007;359:239–44. 174:2041–5.
J Sex Med 2009;6(suppl 3):320–327