Page 89 - Mesenchymal Stem cells, Exosomes and vitamins in the fight aginst COVID

Pain Physician: August 2020 COVID-19 Special Issue 23:S391-S420

Improvement of LVEF in ICF and NICF. Decrease of LVESD and B natriuretic peptide only No change in LVEF, EF, LVEDV, BMC transplantation within 24 hours or at 3–7 days after PCI further improved cardiac function, whereas BMC infusion performed later (7–30 days after PCI) offered no additional Increase in myocardial salvage No change if given 5–7 days or No change in LVEF, scar volume, wall motion score index. Improvement in LVEF, NYHA

Findings in NICF. and LVESV. benefits. index (3 days). 3–4 weeks after MI. LVEF.

Follow- Up 6 12 12 12 12 6 12 12 3

LVEF Impact Yes - improvement No Yes No No No Yes - improvement Yes - improvement No

Outcome Yes No Yes Yes No No Yes Yes No

Condition HF DCM IHD IHD IHD IHD HF DCM HF

Delivery Method CS IC IC IC IC IC IV IC IC

Type of Stem Cell BMC BM MNC BM MNC BM MNC BM MNC BM MNC UC MSC BM MNC, BM MSC BM MNC

Number of SCs 3.7 billion 2.36 billion 490 million 59.8 million 139–159 million 420 million 1 million/kg [Pas 3] 510 million MNC, 490 million [Pas 3] MSC 6–8 million

Table 2 con't. MSC therapy studies treating cardiac failure.
BMA (mL) 240 100 Not disclosed 100 65–70 100 NA 80–100 100

No. of Patients in Treatment Group 24 57 79 55 95 11 15 16, 17 30

Type of Study RCT RCT Controlled trial RCT PCT RCT RCT RCT PCT

Year 2015 2015 2015 2016 2016 2011 2017 2017 2018

Author Patel et al, Stem Cells Transl Med 2015; 4:1021-1027 Martino et al, Eur Heart J 2015; 36:2898-2904 Huang et al, Stem Cell Res Ther 2015; 6:112 Choudry et al, European Heart Journal 2016; 37:256-263 Sürder et al, Circ Res 2016; 119:481-490 Srimahachota et al, J Med Assoc Thai 2011; 94:657-663 Bartolucci et al, J Med Assoc Thailand 2017; 121:1192-1204 Xiao et al, Int Heart J 2017; 58:238-244 Mostafavi

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