Page 17 - CASA Bulletin of Anesthesiology 2022; 9(5)

Vol. 9, No 5, 2022

medication and we did not collect data on their psychiatric reaction to the KE6-2-2 mixture.
However, from observation, most of the elderly patients’ experience was positive (feelings of
peace, healing, spirituality, joyful) or neutral (adventures, “psychedelic”). A small group of
young patients’ experience was negative (“bad dreams”) which was improved with midazolam
administration intraoperatively. Midazolam pre-treatment seems helpful in preventing such
effects.

In conclusion, our single syringe multimodal KE6-2-2 mixture provides quality opioid-free
sedation in patients undergoing ophthalmic surgery, which is applicable to other diagnostic and
surgical procedures. Its analgesic effect was similar to that of the opioid-based A6-2-2 mixture,
but its onset was much quicker, with superior airway and hemodynamic safety profiles.

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