Page 19 - CASA Bulletin of Anesthiology 2021, Vol 8, No. 6 (1)

Vol. 8, No. 6, 2021

These have led to speculation of potential neurotropism, with both muscle and neural tissue
expressing angiotensin-converting enzyme 2 (ACE2) receptor, and COVID-19 virus is also
associated with neural injury, including axonopathic polyneuropathy. 25

Fig. 3 Long term sequelae of COVID-19 in the central nervous system and possible mechanisms
causing Post-COVID-19 fatigue.

Many reports have now emerged on the post-acute infectious consequences of COVID-19,
with studies from the United States, Europe and China reporting outcomes for those who have
survived an acute COVID-19 infection. The findings from studies reporting outcomes in ongoing
symptomatic post COVID-19 and long COVID, and post-COVID-19 syndrome are summarized
in Table 2.

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