Page 207 - Critical Maternity & Newborn Health Nursing

(I) Congenital (Intracorpuscular):

1-Spherocytosis.

2- Haemoglobinopathies;

a- Thalassemia:

α - thalassemia

1. Major.

2. Minor.

β- thalassemia

1. Major.

2. Minor.

b-Sickle cell anemia.

3-Glucose -6- phosphate dehydrogenase deficiency (G-6-PD).

(II) Acquired (Extra corpuscular):

1- Chemicals: e.g. Drugs, Lead and Snake Venum.

2- Infections: e.g. Malaria and Clostridium Welchii.

3- Hypersplenism.

Congenital Spherocytosis

An autosomal dominant disorder in which there is deficiency in the

lipoprotein of cell membrane leading to increased rigidity of the RBCs and

hence its destruction especially in the spleen.

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