Page 117 - Ebook-Book JCMS 2025

Exploring the Connection between Functional Dyspepsia and
Sleep Disorders: Unraveling the Link.
Winrada Khomate, Wannisa Wongpipathpong, Thanyakamol Phongnarudech, Nuttapat Tungtrongchitr*
Chakri Naruebodindra Medical Institute, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
*Corresponding Author E-mail: nuttapat.tun@mahidol.edu
Background: Abstract
Functional dyspepsia is a common gastrointestinal disorder with unknown causes.
Though a potential link between sleep disorders and digestive issues exists, evidence is
inconclusive. This study aims to explore this relationship.
Methods: This prospective study was conducted at a medical school hospital from January 2023
to November 2023. Patients diagnosed with functional dyspepsia, according to the Rome
IV criteria, were classified into two subtypes. Investigations were undertaken to exclude
other potential diagnoses, which included a blood test, abdominal ultrasound, and upper
endoscopy with H. pylori testing. We measured patients’ sleep quality and daytime alertness
with the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS).
Results: A total of 134 patients were diagnosed with functional dyspepsia after careful evaluation.
Among them, functional dyspepsia with postprandial distress syndrome predominate group
(FD-PDS) was found at 60.4%. FD-PDS was linked to a higher PSQI score, with an average
of 8.47 (p < 0.05). Additionally, there was a positive association between FD-PDS and the
sleep quality (p < 0.05). The FD-PDS group was significantly associated with excessive
daytime sleepiness (p < 0.05). Interestingly, the PSQI and ESS scores correlated with
FD-PDS, with correlation coefficients yielding a p-value of less than 0.05.
Conclusion: The findings indicate that FD-PDS is associated with elevated PSQI severity and abnormal
ESS scores. Sleep disorder assessment should be conducted alongside evaluation in
patients with functional dyspepsia, especially those with postprandial distress syndrome.
Harmony in health: Innovation for Sustainable Medicine
115