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Results: Conclusions: A total of 65 patients were included, 24 patients (37%) were confirmed diagnosed TS and
used as a reference test. QFT-GIT demonstrated an accuracy of 79.66%, sensitivity of
82.61%, and specificity of 77.78% for TS diagnosis. No significant differences were found
in the proportion of overall MAIT cells, CD4+ MAIT, CD8+ MAIT, and Double negative (CD4-
CD8-) MAIT when compared between TS and non-TS patients. However, the MAIT cell
population in CD8+ T lymphocytes was significantly higher in patients with TS (p=0.0081).
CD8+ MAIT cell percentage > 5.41% demonstrated fair discriminative ability, with an AUC
of 0.746, sensitivity of 64.3%, and specificity of 82.9%. Combining QFT-GIT and CD8+ MAIT
cells improved specificity to 96.9%.
QFT-GIT and MAIT cells analysis are promising, non-invasive diagnostic tools with
moderate sensitivity and specificity for differentiating TS in spondylodiscitis patients,
particularly when tissue diagnosis is not feasible, to avoid delayed diagnosis and initiation
of treatment.
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