Page 19 - Quanta BioDesign Catalog 5-17-18

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Payload Delivery dPEG Reagents
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Payload Delivery dPEG Reagents Sidewinder™ dPEG Constructs - Proprietary - Offered under MTA and license
SidewinderTM dPEG® Constructs - Proprietary - Offered under MTA and license
Quanta BioDesign, Ltd. offers
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Sidewinder™ dPEG Constructs
Proprietary and available for evaluation under an MTA

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Quanta BioDesign scientists have designed a new class of dPEG constructs, the Sidewinder™ dPEG s, which offer a unique opportunity
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for taking advantage of dPEG properties. These additions open a vast range of new ways to incorporate the dPEG to optimize PK and
BD properties for any targeting species in diagnostic and therapeutic applications.
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The proprietary in-house expertise developed and utilized by Quanta for processing dPEG constructs as single molecules, allows us to
make this exceptional offering under a variety of business relationships.
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The foundation of the Sidewinder™ dPEG concept is the ability to add distinct therapeutic or diagnostic moieties onto one or more
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functionalized side-arms, with a “naked” dPEG construct extending into the in vitro or in vivo medium. This masks the payload on the
targeting agent as it moves to or interacts selectively with the site of interest.
All of the ideal properties of the PEG moiety are in play.

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The “naked” dPEG can serve a number of functions when attached to a targeting moiety:
 Masking a drug or diagnostic agent from interacting with the medium; e.g. optimizing PK and increasing solubility in ADC
applications 2
 Increasing cell internalization of cell surface antigen targeting species
 Reducing non-specific interactions and aggregation for improved BD and decreased immunogenicity

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Additional features include our ability to make the Sidewinder™ dPEG constructs with multiple moieties; allowing one to either
multiplex at a single point of attachment or attach different moieties on a single construct, including, e.g., both a therapeutic and
diagnostic, as well as building on a dendritic core.

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As with all of Quanta BioDesign’s other dPEG products, ALL of the Sidewinder™ dPEG constructs are being developed and
manufactured completely and exclusively in Ohio, USA.

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“Ready to Use” Sidewinder™ dPEG products

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Several general structural representations of Sidewinder™ dPEG constructs that Quanta BioDesign has made or can be made
available through collaboration under an MTA, are represented infra.
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This technology continues to evolve as we explore new dPEG x/y options, as well as functional group and orthogonal chemistry
combinations; please contact us for more information to discuss how we can help you optimize your application.

1. Patents pending.
2. Reducing hydrophobicity of homogeneous ADCs improves PK and TI. R.Lyon, et al., Nature Biotechnology, 33, 733-735
(2015).

For quotes on bulk quantities, please contact info@quantabiodesign.com 13