Page 29 - Quanta BioDesign Catalog 5-17-18

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dPEG Based Chemical Modification Reagents
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dPEG Based Chemical Modification Reagents Branched dPEG PK Modifiers - Proprietary - Offered under MTA and license
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Branched dPEG
MTA and license PK Modifiers - Proprietary - Offered under MTA and license
Quanta BioDesign, Ltd. offers
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Branched dPEG PK Modifiers*
Proprietary and available for evaluation under an MTA

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Quanta BioDesign’s vision for the dPEG process and product technology has been to offer products that cover a broad
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range of size options in a single molecule dPEG format.
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Through our design of the single molecule dPEG format; a full range of biological applications are provided the
incredible benefits and outstanding properties of PEG, but in a single molecule format.

Conventional polymeric PEGs have generally been used as high MW polymers to modify serum half-life of biologics.
These products are problematic as they are uncharacterized and contain hundreds of different active species with a
broad range of activities.

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With the design options that the dPEG offers, they can be made into constructs that are not available using the
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conventional polymeric PEG format. The inherent single molecule nature of the dPEG construct allows for full
characterization of conjugated, labelled and modified products. It is routine to monitor conjugations via MALDI-TOF
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MS with our dPEG constructs.

To present a complete range of hydrodynamic volumes for modulating PK, we are offering our proprietary single
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molecule branched dPEG s through collaboration under a MTA. This empowers the scientist to innovate with a
powerful new set of tools.

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The branched dPEG s, each being a single molecule, allows multiple constructs to be added without fear of losing the
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ability to precisely characterize the dPEG ylated biologic, even in a random conjugation format. If different functional
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sites are available, then different MW’s or different types of dPEG constructs can be incorporated.
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Concomitant with the ability to modulate the PK comes the benefit of the dPEG to enhance BD (in vivo S/N) as dPEG s
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minimize or eliminate non-specific binding. They are also designed NOT to block binding sites by keeping the dPEG x in
a MW range for it to be primarily hydrogen bonded. All of the positive properties of PEG, which make it non-
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immunogenic and non-toxic, are inherent in these dPEG products as well.
Work with Quanta BioDesign to optimize the performance of your therapeutic or diagnostic applications, using the
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branched dPEG PK modifiers and any of our other high quality dPEG constructs - all developed, processed and
manufactured at commercial scale in Ohio, USA.

*Patent’s Pending

Additional References can be found at the end of each category 23