Page 2 - PC 101 practical notes 24-25..

MANSOURA NATIONAL UNIVERSIY
PHARM D- CLINICAL PHARMACY LEVEL I PHARM. ANAL. CHEM. I (PC 101)

Contents

S Su ub bj je ec ct t P Pa ag ge e

S Sa af fe et ty y a an nd d L La ab bo or ra at to or ry y R Ru ul le es s 3

C Ch ha ap pt te er r I I: : I In nt tr ro od du uc ct ti io on n 7
Classification of Analytical Chemistry Branches ……………..….. 8

Standard Solutions ………………………………………………….……….…………. 10

Methods of expressing the concentration ……….…………………….. 11

C Ch ha ap pt te er r I II I: : A Ac ci id d- -B Ba as se e T Ti it tr ra at ti io on n 14

Acid-base indicators ……………………………………………………..……………. 15
Steps for the determination of a sample using titration ….…... 19

Determination of HCl sample ………………………….………….................... 20

Types of titration methods ………………………….…………………………….. 21
Calculations for volumetric analysis (titration) …………..………… 23

Determination of NH4Cl sample ……..…………….…………………………. 28

Determination of NH4Cl & HCl mixture ……….……….………………… 32
Acid-base titration curve ……………………………..……….……………………. 36

Choice of acid-base indicators …………………………..……….…………… 38

Determination of NaOH & Na2CO3 mixture …………………………... 43

Determination of Na2CO3 & NaHCO3 mixture ………………………. 46
Determination of HCl & CH3COOH mixture …………………………. 49

Determination of Aspirin Tablets (Back titration) ….…………. 55

Determination of Boric acid (H3BO3) ………………………………......... 58

Determination of Borax (Na2B4O7) ……..………………………………..… 61

C Ch ha ap pt te er r I II II I: : P Pr re ec ci ip pi it ta at ti io on n T Ti it tr ra at ti io on n 66

Introduction to precipitation titration ……………………………………… 67

Mohr’s Method ………………………………………………………………………….. 68
Determination of NaCl (by Mohr’s method) ………. ………………… 69

Determination of NaBr (by Mohr’s method) ………. ………………… 73

Volhard’s Method ………………………………………………….………………….. 74

Determination of NaCl (by Volhard’s method) ……..……………… 77
Determination of KBr (by Volhard’s method) ……..……………… 84

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