Page 219 - ebook HCC

GENEVA, SWITZERLANDA, SWITZERLAND
PROGRAMME AND ABSTRACTSAND ABSTRACTS
EASL HCC SUMMITHCC SUMMIT
216 PROGRAMME GENEV EASL 217
216
217
FEBRUAR
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
Poster Board Number C13
PRETREATMENT NEUTROPHIL - TO -
LYMPHOCYTE RATIO IN CIRRHOTIC PATIENTS
WITH HCC

Hany R. Shabana , Salah El-Gamal , Ehab Abdel-Khalek , Also, we found that, the higher the NLR, the higher the Child-Pugh score.
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Abd-Elmohsen E. El-Desoky , Talal A. Amer , Ibrahim A. Abdel-Aal , Marwa S. Askar 5 (r = 0.212, p = 0.037).
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1 Internal medicine, specialized medical hospital,mansoura university, Internal medicine, The cut -off value of NLR above it patients had a higher possibility of high Child-Pugh
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specialized medical hospital, Radiodiagnosis, Mansoura university hospital, Clinical score (more than 6) was 2.016. The sensitivity of this cut off value was 62.5% and the
pathology, Mansoura faculty of medicine, Mansoura, Blood Bank, specificity was 54.5%.
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Aga hospital,Ministry of health, Aga, Egypt There was a significant positive correlation between the NLR and the AST/ALT ratio
(r = 0.240, p =.022).
Corresponding author’s e-mail: hanyshabanahanyshabana@yahoo.com
Conclusions: Pretreatment high NLR is associated with more advanced tumour stage
and more degree of liver function impairment in cirrhotic patients with HCC.
Introduction: Neutrophil-to-lymphocyte ratio (NLR) is associated with prognosis in many
cancers. Accumulating evidence suggest that there is a prognostic value of the NLR in Figure 1: NLR with TNM Stage
HCC cases. Also, NLR has a role in predicting HCC response to both surgical and non
surgical treatment.
Aims: Our aim was to examine the correlation of the pretreatment NLR with the two most
important factors affecting the prognosis of HCC cases, the tumour burden and the degree
of liver function impairment .We also aimed at defining the possible cut-off values of NLR
in relation to these factors.
Methodology: 97 consecutive cirrhotic patients, 86 males (88.7%) and 11 females
(11.3%) was diagnosed as having HCC based on the EASL criteria .Serology for HCV
was positive in 94 cases (96.9%). Neutrophil- lymphocyte ratio (NLR) was calculated by
CLINICAL POSTER ABSTRACTS Child-Pugh score of each patient was calculated. Transaminases levels were measured CLINICAL POSTER ABSTRACTS
dividing the neutrophil count by the lymphocyte count, provided that there was no ongoing
infection. Tumour staging was done using Seventh edition TNM staging system for HCC.
and AST/ALT ratio was calculated.
Results: We found that the higher the NLR, the more advanced the TNM tumour stage
(r = 0.304, p = 0.003).
The cut-off value of NLR above it patients had a higher possibility of advanced tumour
stage (beyond TNM stage II) was 2.25. The sensitivity of this cut- off value was 58.6 %
and the specificity was 66.7%.