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Chapter 3 – Redesigning Biologics

for Immune Durability

3.0 – Opening Framing: Starting with the
Immune System

We’ve spent the last two chapters diagnosing the problem.
Tolerization isn’t rare. It isn’t random. And it isn’t being
solved by the current generation of biologics. The immune
system is doing exactly what it was built to do: identify,
assess, and neutralize foreign proteins introduced into the
body—especially when those proteins arrive through
unnatural routes, in high doses, and without context.

And that’s the part we’ve been ignoring.

Biologics weren’t designed for immune acceptance. They
were designed to perform.
To bind. To block. To suppress.
To win the fight—not avoid it.

But what if that approach is backward?
What if biologics didn’t need to overpower the immune
system?
What if they could be taught to coexist with it?

The truth is, the immune system isn’t just a defense
mechanism. It’s a learning system. One that’s constantly
distinguishing between threat and tolerance, between
danger and familiarity. It does this not through brute force,
but through a deeply evolved choreography—exposures in
the right context, at the right dose, through the right
pathway. It learns. It adapts. It remembers.

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