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VTE and IBD: did you know they were related?

Children with inflammatory bowel disease (IBD) have a higher risk for venous
thromboembolism (VTE), according to a study published in the Journal of

Crohn's & Colitis. Researchers from the Hospital for Sick Children in Toronto
1
and collaborators reported approximately 14-fold higher risk for VTE in

children with IBD compared with the general pediatric population. 1

Children younger than 16 years of age with IBD were identified using validated
algorithms and were compared to age- and sex-matched children without IBD.
1
The data was well-supported by a systematic literature review to estimate the
incidence of VTE in general pediatric population. 2

VTE incidence was found to be 14 times higher than the pooled incidence rate

in the general pediatric population (P <0.001). VTE occurred less often in
1
children with Crohn's disease than among those with ulcerative colitis. Similar
1
trend was reported for deep vein thrombosis and pulmonary
embolism. 1

Patients with IBD who develop deep vein thrombosis or

pulmonary embolism often have active disease at the time of
thromboembolism. This study highlighted that pediatric IBD
2
patients, especially the hospitalized ones, are at high risk of VTE
with potentially negative outcomes. Thus, adequate
2
thromboprophylaxis should be recommended for all hospitalized
patients with active IBD [ulcerative colitis]/[unclassified] and

moderate-to-severe Crohn’s disease with at least one additional
VTE risk factor. 2

Reference

1) Aardoom MA, Klomberg RCW, Kemos P, et al. The incidence and characteristics of venous thromboembolisms in paediatric-onset inflammatory bowel
disease; a prospective international cohort study based on the PIBD-SETQuality Safety Registry. J Crohns Colitis. 2021 (published online).
2) Grainge MJ, West J, Card TR. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet.
2010;375(9715):657-663.