Page 212 - AAOMP Onsite Booklet

2018 Joint IAOP - AAOMP Meeting

Role of matrix metalloproteinases in tumor growth and
invasion; focus on Basal cell carcinoma and Squamous cell

carcinoma of head and neck.

Tuesday, 26th June - 16:30 - Stanley Park Ballroom – Salon 2 - Oral

Dr. rabia safdar (University of Health Sciences, Lahore), Prof. Nadia Naseem (University of Health Sciences Lahore Pakistan), Dr.
Varda Jalil (superior university Lahore), Prof. Abdul Hanan Nagi (retired (ex prof of university of health sciences, Lahore))

OBJECTIVE
To determine the Matrix metalloproteinase (MMP) 9 & 14 expression in Head and Neck Squamous cell carcinoma
(HNSCC) and Basal cell carcinoma (BCC) respectively and to determine if there is any relation between MMPs ex-
pression with HNSCC grade and morphological subtype of BCC.
FINDINGS
49 HNSCC & 42 BCC cases were selected. Sections were microscopically scored using scoring criteria by Kamat et
al: intensity (0-3), proportion (0-3), overall score (intensity+proportion). Tumors were categorized into low and
high expression groups. Among HNSCC cases, 36.7% showed strong staining intensity of MMP 9 antibody in tumor
cells, 28.6% showed moderate, 32.7% weak &only 2% showed negative staining, while 51% cases had strong stain-
ing intensity in stroma adjacent to tumor, 26.5% moderate, 20.4% weak & 2% showed negative staining. For 6.1%
cases overall expression was weak while 93.9% showed high expression. Statistical relation between histological
grade & overall expression as well as overall expression for stroma with tumor invading front staining intensity
were significant by applying Mann-Whitney U test.
For BCC cases, 47.6% showed strong staining intensity of MMP 14 in tumor cells, 45.2% moderate & 7.1% had weak
staining intensity while 35.7% cases had strong intensity of MMP 14 antibody staining in stroma, 45.2% moderate
& 19% cases showed weak staining intensity. Statistical relation between overall expression for tumor & morpho-
logical grades of BCC & between morphological grade & MMP 14 staining intensity at tumour invading front were
significant.
CONCLUSION
MMPs produced by tumor cells and adjacent stroma play significant role in tumor progression. Our results clearly
demonstrate marked expression of MMP 9 & 14 in high grade HNSCC & in high risk morphological grades of BCC
respectively. So targeted therapy protocol for MMPs may represent helpful approach as adjuvant in treatment for
patients at the initial stages of HNSCC & BCC.

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