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Chen-Hsi Hsieh: chenciab@gmail.com; chenci28@ym.edu.tw
Tung-Hu Tsai: thtsai@ym.edu.tw
Yu-Jen Chen: chenmdphd@gmail.com
Li-Ying Wang: liying@ntu.edu.tw
*Corresponding author:
Dr. Chen-Hsi Hsieh
Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial
Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist. New Taipei City 220, Taiwan.
Fax: 886-2- 8966-0906
Phone: 886-2-8966-7000 ext. 1033
E-mail: chenicab@gmail.com; chenci28@ym.edu.tw
Abstract
Background: To evaluate the radiotherapy (RT) - pharmacokinetics (PK) effect of
regorafenib in concurrent or sequential regimens with conventional or high-dose
irradiation.
Methods: In vitro and in vivo concurrent and sequential studies of irradiation and
regorafenib were designed. The interactions of RT and regorafenib in vitro were
