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Figure 4.8. Action potential and pseudo ECG computed from molecular dynamics simulations
of I . A, B, the action potential (V ) and I are shown for several LQT mutations and are color
m
Ks
Ks
coded according to the mutation (A, slow rate CL=1000ms; B, fast rate CL=300ms). C, Action
potential duration as a function of rate. As rate is slowed (cycle length is increased) action
potential duration increases, a normal process of adaptation. However, mutant action potentials
prolong more than control (red) at slow rate, characteristic of LQT (E160A closely overlaps E160K).
D, the simulated pseudo-ECG shows significant QT interval prolongation for the LQT1 mutation
E160K, compared with mild prolongation by the LQT5 mutation L51H, consistent with the clinical
phenotypes. From Silva et. al. [101], courtesy of Proceedings of the National Academy of Sciences
(PNAS)