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Effect of ACEi (lisinopril) and stopping, on proteinuria (mg/24h) in adriamycin nephrosis rats
700 600
500 400 300 200
100
ACEi Placebo
Renal biopsy
Focal Glomerular Sclerosis index
Placebo + Adria
ACEi + Adria
Control
ACEi Wk 10
28 + 6 9+3 6+6
0
0 20 40 60 80 100
Time (days)
Wapstra et al, Experimental Nephrol 1996; Clin Science 1996; JASN 2000
Proteinuria mg/day
