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A28    SCIENCE
                  Friday 15 November 2019
            U.S. superbug infections rising, but deaths are falling




            By MIKE STOBBE                                                                         relied  on  new  data  and  the  CDC  turned  to  new
            AP Medical Writer                                                                      it  recalculated  the  2013  data  sources.  For  exam-
            NEW  YORK  (AP)  —  Drug-                                                              numbers, resulting in larger  ple, some earlier estimates
            resistant  “superbug”  infec-                                                          baseline estimates.          were  based  on  reports
            tions  have  been  called  a                                                           The  2013  report  estimat-  from  about  180  hospitals.
            developing nightmare that                                                              ed  more  than  23,000  U.S.  This time, CDC was able to
            could  set  medicine  back                                                             deaths  and  more  than  draw  from  the  electronic
            a  century,  making  con-                                                              2  million  infections  each  health records of about 700
            quered germs once again                                                                year from superbugs. Those  U.S. hospitals.
            untreatable.                                                                           numbers were based on 17  Among  the  CDC’s  other
            So  there’s  some  surprising                                                          germs  that  were  consid-   findings:
            news  in  a  report  released                                                          ered the greatest threat.    —There  were  fewer  cases
            Wednesday: U.S. superbug                                                               That count did not include  of  several  nasty  hospital-
            deaths appear to be going                                                              deaths and illnesses from a  associated  germs,  includ-
            down.                                                                                  nasty  bug  called  Clostrid-  ing  drug-resistant  tubercu-
            About  36,000  Americans                                                               ium  difficile,  because  the  losis and the bug known as
            died from drug-resistant in-  This 1971 microscope image made available by the Centers for   germ  still  is  cowed  by  the  MRSA.
                                         Disease  Control  and  Prevention  shows  Neisseria  gonorrhoeae
            fections in 2017, down 18%   bacteria, which causes the sexually transmitted disease gonor-  drugs used to treat it. But C.  —Infections  from  a  so-
            from  an  estimated  44,000   rhea.                                                    diff is considered part of the  called  “nightmare  bacte-
            in 2013, the Centers for Dis-                                         Associated Press  larger  problem,  because  ria”  —  carbapenem-resis-
            ease  Control  and  Preven-                                                            it  can  grow  out  of  control  tant  Enterobacteriaceae,
            tion estimated. The decline  the report says.             widely  available  in  the  when  antibiotics  kill  other  or  CRE  —  held  steady  in-
            is  mainly  attributed  to  an  For  example,  urinary  tract  1940s,  and  today  dozens  bacteria.  C.  diff  infections  stead of increasing, to the
            intense effort in hospitals to  infections have been easily  are used to kill or suppress  and  deaths,  fortunately,  relief of health officials.
            control  the  spread  of  par-  treated  in  doctor’s  offices  the bacteria behind illness-  have also been declining.  Officials credit hospitals for
            ticularly  dangerous  infec-  with  common  antibiotics.  es ranging from strep throat  Overall,  public  health  of-  using  antibiotics  more  ju-
            tions.                       But  it’s  increasingly  com-  to  the  plague.  The  drugs  ficials  acknowledge  the  diciously,  and  to  do  more
            “We are pushing back in a  mon to see young healthy  are  considered  among  superbug problem is prob-              to  isolate  patients  with  re-
            battle we were losing,” said  women  with  such  infec-   medicine’s  greatest  ad-    ably  even  bigger.  A  2018  sistant infections. They also
            Michael  Kirsch,  a  pharma-  tions forced into the hospi-  vances,  and  have  saved  paper   suggested    more  believe  government  fund-
            cist  at  AdventHealth  Tam-  tal  after  initial  treatments  countless lives.        than 153,000 Americans die  ing  for  laboratories  has
            pa,  a  Florida  hospital  that  don’t work, said Dr. Bradley  But  as  decades  passed,  each  year  with  —  though  helped  investigators  labs
            has  seen  lower  superbug  Frazee,  a  California  emer-  some  antibiotics  stopped  not  necessarily  from  —  su-  more  quickly  spot  drug-
            infection rates. “I would not  gency room doctor.         working.  Experts  say  their  perbug infections.         resistant  germs  and  take
            by any means declare suc-    “We  never  really  worried  overuse  and  misuse  have  The  difference  stems  from  steps against them.
            cess.”                       about this kind of antibiotic  helped make them less ef-  where researchers get their  Still,  CDC  officials  said
            Indeed,    though   deaths  resistance in the past,” said  fective.                    data and on what’s includ-   there’s  hardly  cause  for
            are  going  down,  nonfatal  Frazee,  who  last  year  co-  The new report marks only  ed.  “There’s  not  universal  celebration. “There are still
            infections  grew  nationally  authored  a  journal  article  the  second  time  the  CDC  agreement on what consti-  way too many people dy-
            from  2.6  million  in  2013  to  documenting  more  than  has  tried  to  measure  the  tutes a drug-resistant infec-  ing,” said Michael Craig, a
            2.8  million  in  2017.  Some  1,000  drug-resistant  urinary  numbers  of  U.S.  illnesses  tion,” said the paper’s lead  leader  in  CDC’s  superbug
            worrisome  new  germs  are  tract infections in one year  and  deaths  attributed  to  author, Dr. Jason Burnham  threat-assessment      work.
            emerging.  And  superbugs  at  Highland  Hospital  in  drug-resistant  germs.  The  of Washington University in  “We have a long way to go
            are appearing much more  Oakland.                         first  was  released  six  years  St. Louis.              before we can feel we can
            often  outside  of  hospitals,  Antibiotics  first  became  ago. This time, the agency  For  Wednesday’s  report,  even get ahead of this.”q

                                                                      Japan spacecraft starts yearlong


                                                                      journey home from asteroid



                                                                      By MARI YAMAGUCHI            Hayabusa2  staff  at  the  (40 miles) from the asteroid
                                                                      Associated Press             command center stood up  and  out  of  its  the  gravita-
                                                                      TOKYO (AP) — A Japanese  and  cheered  when  JAXA  tional pull. After that, Ryugu
                                                                      spacecraft  left  a  distant  project  manager  Yuichi  will be out of its sight.
                                                                      asteroid  on  Wednesday,  Tsuda  confirmed  the  de-      "It's  sad  to  say  goodbye
            This image released on Wednesday, Nov. 13, 2019, by the Ja-  starting  its  yearlong  jour-  parture.               to  Ryugu,"  Tsuda  said  at  a
            pan  Aerospace  Exploration  Agency  (JAXA),  shows  asteroid
            Ryugu taken by Japan’s Hayabusa2 spacecraft.              ney  home  after  success-   The  spacecraft  captured  briefing Tuesday. "Literally it
                                                     Associated Press  fully  completing  its  mission  and  transmitted  to  Earth  has  been  at  the  center  of
                                                                      to gather soil samples and  some  of  its  final  images  of  our  lives  over  the  past  1½
                                                                      data  that  could  provide  Ryugu, or "Dragon Palace,"  years."
                                                                      clues  to  the  origins  of  the  named after a sea-bottom  The  spacecraft  will  then
                                                                      solar  system,  the  country's  castle  in  a  Japanese  folk  ignite  its  main  thrusters  in
                                                                      space agency said.           tale,  as  it  slowly  began  early  December  to  propel
                                                                      The  Japan  Aerospace  Ex-   moving  away,  JAXA  said.  it back to Earth.
                                                                      ploration  Agency  said  the  Hayabusa2 will continue its  "We expect Hayabusa2 will
                                                                      Hayabusa2  spacecraft  left  "farewell filming" of the as-  bring  us  new  scientific  in-
                                                                      its orbit around the asteroid  teroid for a few more days.  sights," Tsuda said.
                                                                      Ryugu, about 300 million ki-  Hayabusa2  will  adjust  its  "Not only the data, but tan-
                                                                      lometers  (180  million  miles)  position  about  Nov.  18  af-  gible samples will be in our
                                                                      from Earth.                  ter retreating 65 kilometers  hands."q
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