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A12   HEALTH
               Thursday 19 November 2020
            Volunteers still needed to test variety of COVID-19 vaccines



            By LAURAN NEERGAARD                                                                                                 so scientists had no idea if
            AP Medical Writer                                                                                                   or  how  well  the  COVID-19
            Two  COVID-19  vaccines                                                                                             candidates might work.
            might  be  nearing  the  fin-                                                                                       Both  manufacturers  are
            ish  line,  but  scientists  cau-                                                                                   working  to  scale  up  pro-
            tion it’s critical that enough                                                                                      duction  in  factories  in  the
            people  volunteer  to  help                                                                                         U.S. and Europe.
            finish  studying  other  can-                                                                                       They  can’t  simply  partner
            didates  in  the  U.S.  and                                                                                         with other vaccine compa-
            around the world.                                                                                                   nies to take on some of the
            Moderna  Inc.  and  com-                                                                                            work because the technol-
            petitor  Pfizer  Inc.  recently                                                                                     ogy is so different than the
            announced  preliminary  re-                                                                                         way  most  of  today’s  shots
            sults showing their vaccines                                                                                        are made.
            appear more than 90% ef-                                                                                            “It  is  not  a  very  easy  or
            fective,  at  least  for  short-                                                                                    quick swap,” said Moderna
            term  protection  against                                                                                           CEO Stéphane Bancel.
            COVID-19.                                                                                                           TROJAN HORSE VACCINES
            If those early results hold up                                                                                      A  different  way  to  target
            and  U.S.  regulators  agree                                                                                        the  spike  protein:  Use  an-
            the  shots  are  safe,  emer-                                                                                       other,  harmless  virus  to
            gency  use  of  small,  ra-                                                                                         carry  the  spike  gene  into
            tioned  supplies  could  start                                                                                      the body. Once again, the
            in late December.                                                                                                   body produces some spike
            Other  countries  with  con-  In this March 16, 2020, file photo, Neal Browning receives a shot in the first-stage safety study of a   protein and primes the im-
            tracts for early doses would   potential vaccine for COVID-19 at the Kaiser Permanente Washington Health Research Institute in   mune system.
                                         Seattle.
            undertake  their  own  re-                                                                         Associated Press   Britain’s  Oxford  University
            views.                                                                                                              and AstraZeneca are mak-
            But  multiple  vaccines  will  of  Health  Director  Francis  portant to complete these  frontrunners  in  the  global  ing  their  version  of  this  “vi-
            be needed to meet global  Collins,  urging  Americans  clinical  trials  and  the  trials  vaccine race:            ral  vector”  vaccine  with  a
            demand and help end the  to sign up.                      of the other vaccines so we  GENETIC CODE VACCINES        cold  virus,  or  adenovirus,
            pandemic, raising concern  Additionally,    participants  can make comparisons.”       The   Moderna-NIH     vac-   that normally infects chim-
            that  studies  that  still  need  in  the  Moderna  and  Pfizer  The  promising  Moderna  cine  and  the  candidate  panzees. Studies of tens of
            to sign up thousands of vol-  studies  who  originally  got  and Pfizer news bodes well  developed  by  Pfizer  and  thousands  of  people  are
            unteers  could  run  short  if  dummy  shots  would  al-  for  some  of  their  competi-  its  German  partner  BioN-  underway  in  the  U.K.,  U.S.
            people wait for an already  most  certainly  be  offered  tors, said Dr. Anthony Fauci,  Tech aren’t made with the  and  several  other  coun-
            OK’d option instead.         the real vaccine if the U.S.  the  U.S.  government’s  top  coronavirus  itself,  meaning  tries.
            “We don’t want to see that  Food and Drug Administra-     infectious  disease  expert  there’s no chance anyone  Johnson  &  Johnson  is  us-
            happen,”  said  Dr.  James  tion allows emergency use.  whose team at NIH helped  could  catch  it  from  the  ing a human adenovirus for
            Cutrell,  an  infectious  dis-  But  no  one  knows  how  develop the Moderna can-     shots. Instead, the vaccines  its  version,  and  is  the  only
            ease  expert  at  UT  South-  long protection would last,  didate.                     are  made  with  a  brand-   option  in  advanced  U.S.
            western  Medical  Center  in  meaning those studies also  Those  shots  target  the  new  technology  that  in-     testing aiming to show if a
            Dallas.                      must  continue  to  track  re-  “spike”  protein  that  studs  jects  a  piece  of  genetic  single dose rather than two
            Supplies  aside,  other  CO-  cipients somehow.“It’s one  the surface of the corona-   code for the spike protein.  would be enough.
            VID-19   vaccines    under  thing  to  be  effective  two  virus,  and  the  early  results  That  messenger  RNA,  or  China’s  government  au-
            development  may  work  months after your last vac-       prove  that’s  enough  to  mRNA, instructs the body to  thorized  emergency  use
            differently in different pop-  cination and another thing  generate “a protective re-  make some harmless spike  of  CanSino  Biologics’  ad-
            ulations  and  “we  likely  to  be  effective  a  year”  sponse,” Fauci said.          protein,  enough  to  prime  enovirus shots in the military
            will  benefit  from  having  a  later,  said  Dr.  Jesse  Good-  “Conceptually  this  looks  the  immune  system  to  re-  ahead of any final testing.
            menu of vaccine options,”  man  of  Georgetown  Uni-      good”  for  other  spike-fo-  act if it later encounters the  Russia  likewise  began  of-
            Cutrell said.                versity, a former director of  cused  vaccines  made  in  real virus.                  fering  an  adenovirus  vac-
            “We  still  need  volunteers,”  the FDA’s vaccine division.  different ways.           There  are  no  licensed  cine  ahead  of  late-stage
            stressed  National  Institutes  “It’s  going  to  be  really  im-  Here’s  a  scorecard  of  the  mRNA vaccines for people,  tests.q

              ‘Dueling dinosaurs’ fossils donated to North Carolina museum


                                                                      RALEIGH, N.C. (AP) — The  to  the  Raleigh  museum’s  museum       paleontologists
                                                                      fossil skeletons of two dino-  vertebrate  paleontology  an  unprecedented  op-
                                                                      saurs  intertwined  in  what  collection.               portunity for research and
                                                                      looks  like  a  final  death  The Tyrannosaurus rex and  education.
                                                                      match  have  been  do-      Triceratops horridus known  The  skeletons  are  worth
                                                                      nated to a North Carolina  as  the  dueling  dinosaurs  millions of dollars and were
                                                                      museum.                     were  buried  together  67  the  subject  of  a  court
                                                                      The nonprofit organization  million years ago.          battle  over  who  owned
                                                                      Friends of the North Caroli-  Their  fossils  were  discov-  them  after  their  discovery
                                                                      na Museum of Natural Sci-   ered on a Montana hillside  in 2006. In June, a U.S. ap-
                                                                      ences said in a statement  and  remain  entombed  peals court ruled the fossils
                                                                      Tuesday  that  it  acquired  within the sediment where  belong  to  the  owners  of
              In this Nov. 14, 2013, file photo, one of two “dueling dinosaurs”   the  fossilized  animals  with  they were found.   the  land’s  surface  rights,
              fossils is displayed in New York.                       private funds.              The nonprofit said the dis-  not the owners of the min-
                                                     Associated Press  The skeletons will be gifted  tinct preservation will give  eral rights.q
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