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A28    SCIENCE
                  Friday 26 January 2018


















            Scientists successfully clone monkeys; are humans up next?



            By MALCOLM RITTER                                                                      scientists implanted 79 em-  age  of  human  cloning  in-
             AP Science Writer                                                                     bryos  to  produce  the  two  volves  making  a  copy  of
            NEW  YORK  (AP)  —  For  the                                                           babies.  Still,  the  approach  someone  already  born.
            first time, researchers have                                                           succeeded  where  others  That  might  be  possible
            used the cloning technique                                                             had  failed.  Poo  said  that  someday, but “I don’t think
            that  produced  Dolly  the                                                             was  because  of  improve-   it should be pursued,” said
            sheep  to  create  healthy                                                             ments  in  lab  techniques  researcher  Dieter  Egli  of
            monkeys,  bringing  science                                                            and  because  research-      Columbia    University.   “I
            an important step closer to                                                            ers added two substances  can’t think of a strong ben-
            being able to do the same                                                              that helped reprogram the  efit.” Henry Greely, a Stan-
            with humans.                                                                           DNA from the fetus. That let  ford  University  law  profes-
            Since  Dolly’s  birth  in  1996,                                                       the  DNA  abandon  its  job  sor  who  specializes  in  the
            scientists   have   cloned                                                             in the fetus, which involves  implications  of  biomedi-
            nearly  two  dozen  kinds  of                                                          things like helping to make  cal  technologies,  said  the
            mammals,  including  dogs,                                                             collagen, and take on the  strongest argument he can
            cats,  pigs,  cows  and  polo                                                          new  task  of  creating  an  think  of  would  be  the  de-
            ponies, and have also cre-                                                             entire  monkey.  The  Chi-   sire  of  grieving  parents  to
            ated human embryos with                                                                nese researchers said clon-  produce  a  genetic  dupli-
            this method. But until now,   In  this  undated  photo  provided  by  the  Chinese  Academy   ing  of  fetal  cells  could  be  cate  of  a  dead  child.  But
            they have been unable to     of  Sciences,  cloned  monkeys  Zhong  Zhong  and  Hua  Hua  sit   combined  with  gene  edit-  he  doubts  that’s  a  com-
            make babies this way in pri-  together with a fabric toy.                              ing techniques to produce  pelling  enough  reason  to
            mates,  the  category  that                                           Associated Press  large numbers of monkeys  undertake  the  extensive
            includes  monkeys,  apes  development, but one that       and Poo said society would  with  certain  genetic  de-   and  costly  effort  needed
            and people.                  requires urgent ethical de-  ban it for ethical reasons.  fects that cause disease in  to  get  such  a  procedure
            “The  barrier  of  cloning  pri-  bate.                   Instead, he said, the goal is  people. The animals could  approved, at least for “de-
            mate  species  is  now  over-  Archbishop  Vincenzio  Pa-  to create lots of genetically  then be used to study such  cades and decades.”
            come,”  declared  Muming  glia, head of the Pontifical    identical  monkeys  for  use  diseases  and  test  treat-  Marcy  Darnovsky,  execu-
            Poo of the Chinese Acad-     Academy for Life, said sci-  in medical research, where  ments. The researchers said  tive  director  of  the  Center
            emy of Sciences in Shang-    entific  progress  must  have   they  would  be  particularly  their initial targets will be Al-  for Genetics and Society in
            hai.  In  a  paper  released  as  its  goal  prioritizing  hu-  valuable because they are  zheimer’s and Parkinson’s.  Berkeley, California, called
            Wednesday by the journal  man life, and said this could   more like humans than oth-   Mitalipov,  noting  the  Chi-  it unethical to subject that
            Cell, he and his colleagues  allow cloned animals to be   er lab animals such as mice  nese  failed  to  produce  new  child  to  “the  psycho-
            announced  that  they  suc-  designed  for  medical  ex-  or rats.                     healthy  babies  from  adult  logical and emotional risks
            cessfully  created  two  ma-  perimentation.              The process is still very inef-  cells,  said  he  suspects  at-  of living under the shadow
            caques.  The  female  baby  But  he  warned  that  many   ficient  —  it  took  127  eggs  tempts  to  clone  babies  of its genetic predecessor.”
            monkeys,  about  7  and  animal  lives  were  lost  in    to  get  the  two  babies  —  from a human adult would  Human  cloning  could  also
            8  weeks  old,  are  named  reaching    the   milestone   and so far it has succeed-   also  fail.  “I  don’t  think  it  require  many  women  to
            Zhong Zhong and Hua Hua.     and that “we must always     ed  only  by  starting  with  a  would be advisable to any-  donate eggs and to serve
            “It’s been a long road,” said  consider  the  effect  of  our   monkey fetus. The scientists  one to even think about it,”  as surrogates, she said.
            one scientist who tried and  interference  in  the  eco-  failed  to  produce  healthy  he said.                    At  the  moment,  because
            failed  to  make  monkeys  system  and  evaluate  the     babies from an adult mon-    Jose  Cibelli,  a  scientist  at  of safety concerns, federal
            and was not involved in the  risks.”  Poo  said  the  feat   key,  though  they  are  still  Michigan  State  University,  regulators in the U.S. would
            new  research,  Shoukhrat  shows  that  the  cloning  of   trying and are awaiting the  said  it  might  be  techni-  not allow making a human
            Mitalipov of Oregon Health  humans is theoretically pos-  outcome  of  some  preg-     cally  possible  someday,  baby by cloning, and inter-
            & Science University. “Final-  sible.  But  he  said  his  team   nancies.  Dolly  caused  a  but  “criminal”  to  try  now  national  scientific  groups
            ly, they did it.”            has  no  intention  of  doing   sensation because she was  because  of  the  suffering  also  oppose  it,  said  bio-
            The Vatican’s top bioethics  that.  Mainstream  scientists   the  first  mammal  cloned  caused  by  the  many  lost  medical  ethics  expert  In-
            official said Thursday that it  generally  oppose  making   from  an  adult.  The  pro-  pregnancies  the  process  soo Hyun of Case Western
            was an important scientific  human  babies  by  cloning,   cedure  was  technically  entails.  If  the  procedure  Reserve University in Cleve-
                                                                      challenging.     Essentially,  became  efficient  enough  land. People for the Ethical
                                                                      the  Chinese  scientists  re-  in  monkeys,  he  said,  soci-  Treatment of Animals con-
                                                                      moved  the  DNA-contain-     ety could face “a big ethi-  demned the monkey-clon-
                                                                      ing  nucleus  from  monkey  cal dilemma” over whether  ing experiments.
                                                                      eggs  and  replaced  it  with  to adapt it for humans. The  “Cloning  is  a  horror  show:
                                                                      DNA  from  the  monkey  fe-  key step of transferring DNA  a  waste  of  lives,  time  and
                                                                      tus.  These  reconstituted  might  be  combined  with  money  —  and  the  suffer-
                                                                      eggs  grew  and  divided,  gene editing to correct ge-    ing  that  such  experiments
                                                                      finally  becoming  an  early  netic disorders in embryos,  cause  is  unimaginable,”
                                                                      embryo,  which  was  then  allowing healthy babies to  PETA  Senior  Vice  President
                                                                      placed  into  female  mon-   be born, he said.            Kathy  Guillermo  said  in  a
                                                                      keys  to  grow  to  birth.  The  Of  course,  the  familiar  im-  statement.q
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