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Management of Systemic Lupus Erythematosus

Appendix 2

CLINICAL QUESTIONS
1. Diagnosis and assessment
• What are the risk factors for SLE?
• What are the accurate investigations to diagnose and assess
SLE?
• What are the classification criteria for SLE?
2. Treatment
• What are the principles of treatment in SLE?
• What are the safe and effective non-pharmacological treatments
in SLE?
 Patient education
 Sun protection
 Nurse-led care
• What are the safe and effective pharmacological treatments in
SLE?
 Analgesics
 Corticosteroids
 Hydroxychloroquine and other antimalarial agents
 Immunosuppressive agents
 Biologics
 Intravenous immunoglobulin
 Plasma exchange
• What are the safe and effective alternative and complementary
medicine in SLE?
• What are the safe and effective organ system-specific treatments
in SLE?
 Mucocutaneous
 Musculoskeletal
 Haematological
 Neuropsychiatric
 Cardio-respiratory
 Renal
3. Monitoring
• What are the effective and safe monitoring in SLE?
 Frequency and interval
 Parameters
 Co-morbidities
- Cardiovascular
- Infection
- Osteoporosis
- Malignancy
 Drug adverse events and complications

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