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5  |  Pharmacological treatment of pain



        VetBooks.ir  Perioperative period  Drugs and protocol  Comments

                              ethadone  .  mg kg i.m., ketamine
             Pre-anaesthetic
                                                          ood analgesia and profound sedation from
             medication      mg kg i.m., medetomidine 1   g kg i.m.  this drug combination enabling i.v. catheter
                                                         placement and reduction of anaesthetic
                                                         agent requirements
             Intraoperative    entanyl    g kg i.v. if there is reaction to   May cause transient apnoea and bradycardia
             analgesia       surgical stimulation, repeat as necessary
                             or convert to infusion at   1   g kg
                             minute
                              etamine infusion 1   g kg minute
             Local anaesthetic/  Consider an epidural in ection of  .1 mg   Epidural morphine provides good analgesia
             regional analgesia   kg preservative-free morphine.  for up to  4 hours, but there is possibility of
             technique       In ltration of laparotomy incision with   failure of administration
                             bupivacaine
             Postoperative   Consider methadone  .  mg kg i.m. at   Consider changing to buprenorphine after  4
             analgesia       the end of procedure if this is around 4   hours (to avoid interaction with morphine
                             hours after pre-anaesthetic medication.   epidural)
                             Pain checks every   hours initially, then   A single dose of NSAID is unlikely to cause a
                             every 4 hours as the patient improves,   problem even if liver function is decreased,
                             with methadone repeated every   4   but avoid if the patient has a coagulopathy
                             hours if painful. Ketamine infusion at
                                g kg min. Non steroidal anti
                             in ammatories if still painful
                    Recommended analgesic protocol for an uncooperative cat with triaditis undergoing exploratory
                    laparotomy for liver and intestinal biopsies.




             References and further                Ayroldi E, Cannarile L,  igliorati   et al.    1    echanisms of
                                                   the anti in ammatory e ects of glucocorticoids  genomic and
             reading                               nongenomic interference with MAPK signaling pathways. The
                                                   FASEB Journal 26, 48   48
             Adler    ,   eller  EB,  Rosow  CE  and  Cochin      1988    he   Bai  ,  iller  ,  an  , Law LS C and  an       1   Lidocaine
             opioid system and temperature regulation. Annual Review of   patch for acute pain management: a meta-analysis of
             Pharmacology and Toxicology 28, 4 9 449  prospective controlled trials.  Current Medical Research and
             Aghighi SA, Tipold A, Piechotta M, Lewczuk P and Kästner SB   Opinion 31,  7   81
                1   Assessment of the e ects of ad unctive gabapentin on   Baldini  , Bagriy  , Aprikian A and Carli       9  Postoperative
             postoperative pain after intervertebral disc surgery in dogs.   urinary retention: anesthetic and perioperative considerations.
             Veterinary Anaesthesia and Analgesia 39, 6 6 646  Anesthesiology 110, 11 9 11 7
             Aguirre   A,  Votta Velis     and  Borgeat  A     1    Practical   Bartel  A  ,  Campoy  L,   artin  lores     et al.     16
             pharmacology in regional anesthesia. In: Essentials of Regional   Comparison of bupivacaine and dexmedetomidine femoral
             Anesthesia, ed. A  aye, R Urman and N Vadivelu, pp. 1 1 1 6.   and sciatic nerve blocks with bupivacaine and buprenorphine
             Springer, New York                    epidural  in ection  for  sti e  arthroscopy  in  dogs.  Veterinary
                                                   Anaesthesia and Analgesia 43, 4   44
             Anderson   B        8    Paracetamol    acetaminophen
             mechanisms of action. Pediatric Anesthesia 18, 91  9 1  Becker  E and Reed  L     6  Essentials of local anesthetic
                                                   pharmacology. Anesthesia Progress 53, 98 1 9
             Anderson      and   ay          8   E ects  of  morphine  and
             fentanyl constant rate infusion on urine output in healthy and   Becker   E  and  Reed   L     1    Local  anesthetics   review  of
             traumatized dogs.  Veterinary Anaesthesia and Analgesia  35,   pharmacological considerations.  Anesthesia Progress  59,
               8   6                               9  1
             Aprea  , Vettorato E and Corletto      11  Severe cardiovascular   Beecroft C and  avies      16  Systemic toxic e ects of local
             depression in a cat following a mandibular nerve block with   anaesthetics. Anaesthesia and Intensive Care Medicine 17, 1
             bupivacaine. Veterinary Anaesthesia and Analgesia 38, 614 618  Benitez ME, Roush JK, McMurphy R, KuKanich B and Legallet
             Aratana     16   N CI A  (bupivacaine liposome injectable   C    1   Clinical e cacy of hydrocodone acetaminophen and
                           ®
             suspension) [online]. Available from: http://www.aratana.  tramadol for control of postoperative pain in dogs following
             com wp content uploads   16  8 N CI A Prescribing   tibial plateau leveling osteotomy.  American Journal of
             Information.pdf                       Veterinary Research 76, 7   76
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