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5 | Pharmacological treatment of pain
VetBooks.ir Perioperative period Drugs and protocol Comments
ethadone . mg kg i.m., ketamine
Pre-anaesthetic
ood analgesia and profound sedation from
medication mg kg i.m., medetomidine 1 g kg i.m. this drug combination enabling i.v. catheter
placement and reduction of anaesthetic
agent requirements
Intraoperative entanyl g kg i.v. if there is reaction to May cause transient apnoea and bradycardia
analgesia surgical stimulation, repeat as necessary
or convert to infusion at 1 g kg
minute
etamine infusion 1 g kg minute
Local anaesthetic/ Consider an epidural in ection of .1 mg Epidural morphine provides good analgesia
regional analgesia kg preservative-free morphine. for up to 4 hours, but there is possibility of
technique In ltration of laparotomy incision with failure of administration
bupivacaine
Postoperative Consider methadone . mg kg i.m. at Consider changing to buprenorphine after 4
analgesia the end of procedure if this is around 4 hours (to avoid interaction with morphine
hours after pre-anaesthetic medication. epidural)
Pain checks every hours initially, then A single dose of NSAID is unlikely to cause a
every 4 hours as the patient improves, problem even if liver function is decreased,
with methadone repeated every 4 but avoid if the patient has a coagulopathy
hours if painful. Ketamine infusion at
g kg min. Non steroidal anti
in ammatories if still painful
Recommended analgesic protocol for an uncooperative cat with triaditis undergoing exploratory
laparotomy for liver and intestinal biopsies.
References and further Ayroldi E, Cannarile L, igliorati et al. 1 echanisms of
the anti in ammatory e ects of glucocorticoids genomic and
reading nongenomic interference with MAPK signaling pathways. The
FASEB Journal 26, 48 48
Adler , eller EB, Rosow CE and Cochin 1988 he Bai , iller , an , Law LS C and an 1 Lidocaine
opioid system and temperature regulation. Annual Review of patch for acute pain management: a meta-analysis of
Pharmacology and Toxicology 28, 4 9 449 prospective controlled trials. Current Medical Research and
Aghighi SA, Tipold A, Piechotta M, Lewczuk P and Kästner SB Opinion 31, 7 81
1 Assessment of the e ects of ad unctive gabapentin on Baldini , Bagriy , Aprikian A and Carli 9 Postoperative
postoperative pain after intervertebral disc surgery in dogs. urinary retention: anesthetic and perioperative considerations.
Veterinary Anaesthesia and Analgesia 39, 6 6 646 Anesthesiology 110, 11 9 11 7
Aguirre A, Votta Velis and Borgeat A 1 Practical Bartel A , Campoy L, artin lores et al. 16
pharmacology in regional anesthesia. In: Essentials of Regional Comparison of bupivacaine and dexmedetomidine femoral
Anesthesia, ed. A aye, R Urman and N Vadivelu, pp. 1 1 1 6. and sciatic nerve blocks with bupivacaine and buprenorphine
Springer, New York epidural in ection for sti e arthroscopy in dogs. Veterinary
Anaesthesia and Analgesia 43, 4 44
Anderson B 8 Paracetamol acetaminophen
mechanisms of action. Pediatric Anesthesia 18, 91 9 1 Becker E and Reed L 6 Essentials of local anesthetic
pharmacology. Anesthesia Progress 53, 98 1 9
Anderson and ay 8 E ects of morphine and
fentanyl constant rate infusion on urine output in healthy and Becker E and Reed L 1 Local anesthetics review of
traumatized dogs. Veterinary Anaesthesia and Analgesia 35, pharmacological considerations. Anesthesia Progress 59,
8 6 9 1
Aprea , Vettorato E and Corletto 11 Severe cardiovascular Beecroft C and avies 16 Systemic toxic e ects of local
depression in a cat following a mandibular nerve block with anaesthetics. Anaesthesia and Intensive Care Medicine 17, 1
bupivacaine. Veterinary Anaesthesia and Analgesia 38, 614 618 Benitez ME, Roush JK, McMurphy R, KuKanich B and Legallet
Aratana 16 N CI A (bupivacaine liposome injectable C 1 Clinical e cacy of hydrocodone acetaminophen and
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suspension) [online]. Available from: http://www.aratana. tramadol for control of postoperative pain in dogs following
com wp content uploads 16 8 N CI A Prescribing tibial plateau leveling osteotomy. American Journal of
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