Page 291 - Feline Cardiology
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298  Section G: Congestive Heart Failure


              large-scale  studies  of  cats  with  CHF  secondary    Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto
              to HCM were highly disparate and ranged from 92–563   DM, et al. The effects of normal as compared with low hematocrit
              days  (Rush  et  al.  2002;  Atkins  et  al.  1992).  Similarly,     values in patients with cardiac disease who are receiving hemodi-
                                                                   alysis and epoetin. N Engl J Med 1998;339:584–590.
              there  are  contradicting  results  regarding  negative     Bettencourt P, Ferreira S, Azevedo A, Ferreira A. Preliminary data on
              predictors  for  survival  in  cats  with  HCM  and  heart   the  potential  usefulness  of  B-type  natriuretic  peptide  levels  in
              failure.  One  study  found  that  survival  was  not  influ-  predicting outcome after hospital discharge in patients with heart
              enced by the age at onset, sex, body weight, or breed, but   failure. Am J Med 2002;113:215–219.
              tachycardia (>200 bpm) at presentation was a negative   Biondo AW, Ehrhart EJ, Sisson DD, Bulmer BJ, De Morais HS, Solter
              prognostic  indicator  (Atkins  et  al.  1992).  In  contrast,   PF. Immunohistochemistry of atrial and brain natriuretic peptides
                                                                   in  control  cats  and  cats  with  hypertrophic  cardiomyopathy. Vet
              another study found that left atrial size and increased   Pathol 2003;40:501–506.
              age  were  independent  negative  prognostic  indicators   Boswood A, Murphy A. The effect of heart disease, heart failure and
              (Rush et al. 2002). Cats that have an identifiable precipi-  diuresis on selected laboratory and electrocardiographic parame-
              tating factor—such as long-acting corticosteroid admin-  ters in dogs. J Vet Cardiol 2006;8:1–9.
              istration,  surgery,  fluid  administration,  or  a  stressful   Boswood  A,  Dukes-McEwan  J,  Loureiro  J,  James  RA,  Martin  M,
                                                                   Stafford-Johnson  M,  et  al.  The  diagnostic  accuracy  of  different
              tachycardic event (e.g., being chased by a dog)—tend to   natriuretic peptides in the investigation of canine cardiac disease.
              live longer than cats with severe HCM and severe left   Brater DC. Diuretic therapy. N Engl J Med 1998;339:387–395.
                                                                   J Small Anim Pract 2008;49:26–32.
              atrial dilation that develop heart failure without a pre-
      Congestive Heart Failure  important marker for severity of disease in people with   Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in
                                                                 Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spirono-
              cipitating event. Increased left atrial volume is also an
                                                                   lactone  in  preventing  myocardial  fibrosis  in  systemic  arterial
                                                                   hypertension. Am J Cardiol 1993;71:12A–16A.
              HCM and was associated with more serious cardiovas-
              cular  events,  greater  diastolic  dysfunction,  and  higher
                                                                   cultured adult rat cardiac fibroblasts: response to angiotensin II
              diastolic  filling  pressures  (Yang  et  al.  2005).  Negative
                                                                   and aldosterone. J Mol Cell Cardiol 1994;26:809–820.
                                                                 Brown NJ, Vaughan DE. Angiotensin-converting enzyme inhibitors.
              prognostic indicators for early cardiovascular mortality
                                                                   Circulation 1998;97:1411–1420.
              in people with acute heart failure include hypotension,
              renal impairment, hyponatremia, clinical congestion at   Buchanan JW, Bucheler J. Vertebral scale system to measure canine
                                                                   heart size in radiographs. J Am Vet Med Assoc 1995;206:194–199.
              the  time  of  discharge,  increases  in  brain  natriuretic   Cannon RO, III, Rosing DR, Maron BJ, Leon MB, Bonow RO, Watson
              peptide  levels  during  therapy,  and  poor  functional   RM, et al. Myocardial ischemia in patients with hypertrophic car-
              capacity at the time of discharge (Gheorghiade and Pang   diomyopathy: Contribution of inadequate vasodilator reserve and
              2009).                                               elevated  left  ventricular  filling  pressures.  Circulation  1985;71:
                                                                   234–243.
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