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298 Section G: Congestive Heart Failure
large-scale studies of cats with CHF secondary Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto
to HCM were highly disparate and ranged from 92–563 DM, et al. The effects of normal as compared with low hematocrit
days (Rush et al. 2002; Atkins et al. 1992). Similarly, values in patients with cardiac disease who are receiving hemodi-
alysis and epoetin. N Engl J Med 1998;339:584–590.
there are contradicting results regarding negative Bettencourt P, Ferreira S, Azevedo A, Ferreira A. Preliminary data on
predictors for survival in cats with HCM and heart the potential usefulness of B-type natriuretic peptide levels in
failure. One study found that survival was not influ- predicting outcome after hospital discharge in patients with heart
enced by the age at onset, sex, body weight, or breed, but failure. Am J Med 2002;113:215–219.
tachycardia (>200 bpm) at presentation was a negative Biondo AW, Ehrhart EJ, Sisson DD, Bulmer BJ, De Morais HS, Solter
prognostic indicator (Atkins et al. 1992). In contrast, PF. Immunohistochemistry of atrial and brain natriuretic peptides
in control cats and cats with hypertrophic cardiomyopathy. Vet
another study found that left atrial size and increased Pathol 2003;40:501–506.
age were independent negative prognostic indicators Boswood A, Murphy A. The effect of heart disease, heart failure and
(Rush et al. 2002). Cats that have an identifiable precipi- diuresis on selected laboratory and electrocardiographic parame-
tating factor—such as long-acting corticosteroid admin- ters in dogs. J Vet Cardiol 2006;8:1–9.
istration, surgery, fluid administration, or a stressful Boswood A, Dukes-McEwan J, Loureiro J, James RA, Martin M,
Stafford-Johnson M, et al. The diagnostic accuracy of different
tachycardic event (e.g., being chased by a dog)—tend to natriuretic peptides in the investigation of canine cardiac disease.
live longer than cats with severe HCM and severe left Brater DC. Diuretic therapy. N Engl J Med 1998;339:387–395.
J Small Anim Pract 2008;49:26–32.
atrial dilation that develop heart failure without a pre-
Congestive Heart Failure important marker for severity of disease in people with Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in
Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spirono-
cipitating event. Increased left atrial volume is also an
lactone in preventing myocardial fibrosis in systemic arterial
hypertension. Am J Cardiol 1993;71:12A–16A.
HCM and was associated with more serious cardiovas-
cular events, greater diastolic dysfunction, and higher
cultured adult rat cardiac fibroblasts: response to angiotensin II
diastolic filling pressures (Yang et al. 2005). Negative
and aldosterone. J Mol Cell Cardiol 1994;26:809–820.
Brown NJ, Vaughan DE. Angiotensin-converting enzyme inhibitors.
prognostic indicators for early cardiovascular mortality
Circulation 1998;97:1411–1420.
in people with acute heart failure include hypotension,
renal impairment, hyponatremia, clinical congestion at Buchanan JW, Bucheler J. Vertebral scale system to measure canine
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the time of discharge, increases in brain natriuretic Cannon RO, III, Rosing DR, Maron BJ, Leon MB, Bonow RO, Watson
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