Page 1078 - Veterinary Immunology, 10th Edition

lamb with type I membranoproliferative glomerulonephritis. The
VetBooks.ir basement membrane thickening. (From Angus KW, Gardiner AC, Morgan
primary lesion in this case is mesangial proliferation with some

KT, et al: Mesangiocapillary glomerulonephritis in lambs. II. Pathological findings and
electron microscopy of the renal lesions, J Comp Pathol 84:319-330, 1974.)

Canine Glomerulopathy

C3 deficiency inherited as an autosomal recessive condition has
been described in Brittany Spaniels (Chapter 4). Many of these dogs

develop type I MPGN, which may lead to renal failure. The lesions
are typical with mesangial proliferation, thickening of the
glomerular capillary wall, and deposition of electron-dense

deposits in the mesangium and subendothelial space. The deposits
contain both IgG and IgM. A familial glomerulopathy has been
observed in Bernese Mountain Dogs. It is associated with MPGN
and interstitial nephritis.

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