Page 233 - Veterinary Immunology, 10th Edition

each other by cross-phosphorylation. Group I cytokine receptors, so
VetBooks.ir JAK kinases. When brought together, the JAK kinases are activated
called because they bind the type I cytokines, associate in the
presence of the ligand to form oligomers and form complexes with

and in turn activate STAT proteins. The activated STAT proteins
then dissociate and activate transcription factors. Group II cytokines
such as the interferons and IL-10 bind receptors that have a similar
mode of action to type I receptors.

The members of the group II cytokine receptor family have a very

different structure. They bind interferons (α, β, γ, and λ) and
members of the IL-10 cytokine family (IL-19, IL-20, IL-22, IL-24, and
IL-26). These receptors also form heterodimers in the presence of
the ligand and signal through the JAK-STAT pathway.

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