Page 746 - Veterinary Immunology, 10th Edition
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FIG. 23.5 The relative concentrations of the major immunoglobulin
classes in serum, colostrum, and the milk of ruminants and
nonruminants.
All of the IgG, most of the IgM, and about half of the IgA in
bovine colostrum are transferred from the bloodstream. In milk, in
contrast, only 30% of the IgG and 10% of the IgA are so derived; the
rest is produced locally by lymphoid tissue within the udder.
Colostrum also contains secretory component both in the free form
and bound to IgA. Colostrum contains many cytokines. For
example, bovine colostrum contains significant amounts of IL-1β,
IL-6, TNF-α, and IFN-γ. Equine colostrum has been shown to
contain IL-4, IL-6, TNF-α and IFN-γ. These cytokines may promote
the development of the immune system in the young animal.
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